Protein Alignment Ir75c and Grik1

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 711
• Identity: 138/711 - (19%)
• Similarity: 250/711 - (35%)
• Gaps: 210/711 - (29%)

  Fly     6 LYRLIVFNLLEINLSNL------MVFHCWSIK--EAFPLVEMLNQNGIFSQYIDVQNPDNLANVH 62
            |||....|:....|.|:      .:...||::  :|.|..|....:|:.:
Mouse   269 LYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGVMT--------------- 318

  Fly    63 KEYLDSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLH----WLLYDEAGNFTK------LT- 116
               .::.|:...|::      ..:.::::|:..:.:...|    |.|.....|..|      ||
Mouse   319 ---TEAALMYDAVYM------VAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374

  Fly   117 ----QLFEGANLSLNADVTYVSREDEERFI------LHDVYNK----GSHLGGKLNITVDQTLQC 167
                ...:|.....:.|:..:..|..|:..      |:.|:.|    .|:.|  ||:|...
Mouse   375 RITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSG--LNMTDGN---- 433

  Fly   168 NRSHCQVKEYLSELHLRPRLQHRMDLSSVTFRLAALVSVLPINSSEEELLEFLNSDRDSH----- 227
                            |.|..:..|  |:..|...:.::|     ||..:.:..||:..:
Mouse   434 ----------------RDRSNNITD--SLANRTLIVTTIL-----EEPYVMYRKSDKPLYGNDRF 475

  Fly   228 ----MDSISRIGNRLIMHTQEILGF--KLHYIWCGTWSVQDAFG---GAIGMLTNESAELCTTPF 283
                :|.:..:.|        ||||  .:..:..|.:..|:..|   |.:..|.:..|:|...|.
Mouse   476 EGYCLDLLKELSN--------ILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPL 532

  Fly   284 VPSWNR---LHYLHP-MTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLL 344
            ..::.|   :.:..| ||    .....::|.|:........||.|..|.:|...  ||...||..
Mouse   533 TITYVREKVIDFSKPFMT----LGISILYRKPNGTNPGVFSFLNPLSPDIWMYV--LLACLGVSC 591

  Fly   345 WMIFHLERHWMQRCLDFIP--------------------SLLSSCLISFGAACIQGSYLMPKSAG 389
             ::|.:.|        |.|                    :||:|.....||...|||.||||:..
Mouse   592 -VLFVIAR--------FTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALS 647

  Fly   390 GRLA------FIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLA-DSSLDVGF----DTV 443
            .|:.      |..::::|      ||:.:.:.|....:.|.|.:...|| .:.::.|.    .|:
Mouse   648 TRIVGGIWWFFTLIIISS------YTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTM 706

  Fly   444 PFTKTYLVSSPRPDIRSLYKQ--KVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVE 506
            .|.|...:|:        |::  ...|.|..:::..:.:||:.|       |.|::.:.:.....
Mouse   707 TFFKKSKIST--------YEKMWAFMSSRQQSALVKNSDEGIQR-------VLTTDYALLMESTS 756

  Fly   507 KHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSKQSRFFSKTKLHTF 570
            ..|:.:...:|.:|....:|..||: ..:.|.||..:|...:::.|.|            |||..
Mouse   757 IEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEG------------KLHMM 809

  Fly   571 SNSF-------------VIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKKFSTI 618
            ...:             ...:|:|....:||.|.....|::.:.|.|..   |..:|.:.|
Mouse   810 KEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI---YKSRKNNDI 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	44/212 (21%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	33/187 (18%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	89/429 (21%)