DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Grid1

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	775	Identity:	147/775 - (18%)
Similarity:	264/775 - (34%)	Gaps:	228/775 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSWPLYRL--IVFNLL-EINLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYIDVQNPD-NLANV 61
            :.|.|..||  ::..|: |:.....::|:. |..:...|...|:|.......:.:|..| |:::|
Mouse   141 LASRPPVRLNDVMLRLVTELRWQKFVMFYD-SEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHV 204

  Fly    62 HKEYLDS----------DLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHW------------- 103
            ......:          |.:|..:.| |....|....|::....|.:::.||
Mouse   205 FTSLFTTMKTEELNRYRDTLRRAILL-LSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEIL 268

  Fly   104 -LLYDEAGNFTKLTQLFEGA-------------------------------NLSLNADVTYVSR- 135
             |::...|..|.:.|:|..|                               ||.|...|..::.
Mouse   269 DLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANA 333

  Fly   136 -----EDEE--------------------RFILHDVYNKGSHLGGK------------------- 156
                 ||.:                    |.:| |...|| |:.|.
Mouse   334 FHRKLEDRKWHSMASLNCIRKSTKPWNGGRSML-DTIKKG-HITGLTGVMEFREDSSNPYVQFEI 396

  Fly   157 LNITVDQTLQCNRSHCQVKEYLSELHLRPRLQHR---MDLSSVTFRLAALVSVL--PINSSEEEL 216
            |..|..:|.  .:...::..:.||..|...||.|   ..|..:|.:   :|:||  |.....|.:
Mouse   397 LGTTYSETF--GKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLK---VVTVLEEPFVMVAENI 456

  Fly   217 LEFLNSDRDSHMDSISRIGNRLIMHTQEILGFKL-----------HYIWCGTWSVQDAFGGAIGM 270
            |......:...:|.:..:.        :.||||.           |.:...:|:      |.||.
Mouse   457 LGQPKRYKGFSIDVLDALA--------KALGFKYEIYQAPDGRYGHQLHNTSWN------GMIGE 507

  Fly   271 LTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVF--LEPFMPSVWFAF 333
            |.::.|:|..:....:..|...:........:....:.:.|..   |.::|  ..||..:||...
Mouse   508 LISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEE---KISIFSLFAPFDFAVWACI 569

  Fly   334 AGLLIFAGVLLWMIFHLERHWMQRCLDFIPS----LLSSCLISFGAACIQGSYLMPKSAGGRLAF 394
            |..:...|||::::..::....|......||    |.|:..|.:||...||......|...|:..
Mouse   570 AAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVM 634

  Fly   395 IAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIR 459
            .:..|.:.::.:.||:.:.:.|..|.:.:.|||.|.|: ..|::.:.||..:..|
Mouse   635 GSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS-KQLEMSYGTVRDSAVY---------- 688

  Fly   460 SLYKQKVESKRDPNS----VW-------------LSPEEGVIRVRDQPGFVYTSEASFMYHFVEK 507
            ..::.|..:..:.:|    :|             .:|.||:.:.:       ....:|::.....
Mouse   689 EYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAK-------KGNYAFLWDVAVV 746

  Fly   508 HYLPREISDLNEIIL--RPESAVYGM-VHLNSTYRQLLTQLQVRMLETG---------------- 553
            .|......|.:..::  ...|..||: :...|.||.|.:|..:.:.:||
Mouse   747 EYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRC 811

  Fly   554 -ITSKQSRFFSKT-----KLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW 607
             :||..|   ::|     |||:|:..|.|             |.:...||.|:..||:.|
Mouse   812 DLTSHSS---TQTEGKSLKLHSFAGVFCI-------------LAIGLLLACLVAALELWW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	49/248 (20%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		53/300 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	49/287 (17%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	77/407 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740