DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Gria4

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	511	Identity:	101/511 - (19%)
Similarity:	200/511 - (39%)	Gaps:	78/511 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 HLGGKLNITVDQTLQCNRSHCQVKEYLSELHLRPRLQHR----MDLSSVTFRLAALVSVLP---- 208
            |.|.::|.|:| ..:...:..:...|.:::.....:|..    .|.:::..|...:.:::.
Mouse   365 HYGRRVNYTMD-VFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYV 428

  Fly   209 INSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSVQDA----FGGAIG 269
            :.....|:.|..:......:|..|.|...:      .:.:|:..:..|.:..:||    :.|.:|
Mouse   429 MYKKNHEMFEGNDKYEGYCVDLASEIAKHI------GIKYKIAIVPDGKYGARDADTKIWNGMVG 487

  Fly   270 MLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFA 334
            .|....||:...|...:..|...:.............|.:.|..:......||:|....:|....
Mouse   488 ELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 552

  Fly   335 GLLIFAGVLLWMI-------FHLE--RHWMQRCLDFIPS---LLSSCLISFGAACIQGSYLMPKS 387
            ...|...|:|:::       :|.|  ....:...|..|:   :.:|...|.||...||..:.|:|
Mouse   553 FAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRS 617

  Fly   388 AGGRLA-----FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPF 445
            ..||:.     |..:::.|....|....:.|..:: ||:.|  ::....::|..:||.|.....|
Mouse   618 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDSGSTKEFF 681

  Fly   446 TKTYLVSSPRPDIRSLYKQKVESKR--DPNSVWLSPEEGVIRVRDQPG-FVYTSEASFMYHFVEK 507
            .::.:         ::|::.....|  :|:....:..|||.|||...| |.:..| |.|..::|:
Mouse   682 RRSKI---------AVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE-STMNEYIEQ 736

  Fly   508 HYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF-------- 562
                |:..|..::....:|..||: ....|:.|..:....:::.|.|:..| :::::
Mouse   737 ----RKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGP 797

  Fly   563 ----SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKK 614
                ||.|....|.|.|        |.:|..|:....||:|:.::|.|:...|:.|
Mouse   798 KDSGSKDKTSALSLSNV--------AGVFYILVGGLGLAMLVALIEFCYKSRAEAK 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	53/247 (21%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	6/35 (17%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	77/401 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840