DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Gria2

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	710	Identity:	138/710 - (19%)
Similarity:	254/710 - (35%)	Gaps:	193/710 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NPDNLANVHKE------YLDSDLVR-LGVFLDLGCDKAELVTNQSSRARLYNQNLHWLLYD---E 108
            |..|:.|..|:      :.|.:|.: ..|.||...||...:.:|......:.:..|:::.:   .
Mouse   179 NVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFT 243

  Fly   109 AGNFTKLTQLFEGANLS----LNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVDQTLQCNR 169
            .|:..|:.  |.|||:|    ::.|.:.||:..|....|.:....|:|     ..|:..|.....
Mouse   244 DGDLLKIQ--FGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAH-----TATIKYTSALTY 301

  Fly   170 SHCQVKEYLSELHLRPRLQHRMDLS------------------------------------SVTF 198
            ...||   ::|.....|.| |:::|                                    ::.|
Mouse   302 DAVQV---MTEAFRNLRKQ-RIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKF 362

  Fly   199 -----RLAALVSVLPINS---------SEEELLEFLNSDRDSHMDSISRIGNRLIMHT------- 242
                 |:...::::.:.:         ||.:.:....::..|..|: |.:.|:.::.|
Mouse   363 DQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT-SGLENKTVVVTTILESPY 426

  Fly   243 ------QEIL---------------------GF--KLHYIWCGTWSVQDA----FGGAIGMLTNE 274
                  .|:|                     ||  ||..:..|.:..:||    :.|.:|.|...
Mouse   427 VMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYG 491

  Fly   275 SAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIF 339
            .|::...|...:..|...:.............|.:.|..:......||:|....:|.......|.
Mouse   492 KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIG 556

  Fly   340 AGVLLWMI-------FHLERHWMQRCLDFIPS-----LLSSCLISFGAACIQGSYLMPKSAGGRL 392
            ..|:|:::       :|.|.....|......|     :.:|...|.||...||..:.|:|..||:
Mouse   557 VSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 621

  Fly   393 A-----FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPFTK--- 447
            .     |..:::.|....|....:.|..:: ||:.|  ::....::|..:||.| .|..|.:
Mouse   622 VGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTEIAYGTLDSG-STKEFFRRSK 684

  Fly   448 --------TYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPG-FVYTSEASFMYH 503
                    ||:.|:                 :|:....:..|||.|||...| :.|..| |.|..
Mouse   685 IAVFDKMWTYMRSA-----------------EPSVFVRTTAEGVARVRKSKGKYAYLLE-STMNE 731

  Fly   504 FVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF---- 562
            ::|:    |:..|..::....:|..||: ....|:.|..:....:::.|.|:..| :::::
Mouse   732 YIEQ----RKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKG 792

  Fly   563 --------SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKK 614
                    ||.|....|.|.|        |.:|..|:....||:|:.::|.|:...|:.|
Mouse   793 ECGAKDSGSKEKTSALSLSNV--------AGVFYILVGGLGLAMLVALIEFCYKSRAEAK 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	55/256 (21%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	40/229 (17%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	79/404 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840