Protein Alignment Ir75c and Gria1

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 706
• Identity: 150/706 - (21%)
• Similarity: 263/706 - (37%)
• Gaps: 134/706 - (18%)

  Fly     7 YRLIVFNLLEINLSNLMVFHCWS--IKEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHKEYLDSD 69
            ||:: |..||.....|:|..|.|  :......:..|.:|||...||       |||:  .::|.|
Mouse   185 YRML-FQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYI-------LANL--GFMDID 239

  Fly    70 LVRLGVFLDLGCDKA--ELVT-NQSSRARLYNQ----------NLHW--------LLYDEAGNFT 113
            |.:   |.:.|.:..  :||. ..:..||:..|          .:.|        |.||......
Mouse   240 LNK---FKESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMA 301

  Fly   114 KLTQLFEGANLSL-----------NADVTYVSREDEERFILHDVYNKG-------SHLGGKLNIT 160
            :..|......:.:           |..|.:....|.:| .|..|..:|       :..|.:.|.|
Mouse   302 EAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQR-ALQQVRFEGLTGNVQFNEKGRRTNYT 365

  Fly   161 VDQTLQCNRSHCQVKEYLSE----LHLRPRLQHRMDLSSVTFRLAALVSVL--PINSSEEELLEF 219
            : ..::......:...|.:|    :......|...|.|||..|...:.::|  |....::...:|
Mouse   366 L-HVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQF 429

  Fly   220 LNSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSVQD----AFGGAIGMLTNESAELCT 280
            ..:||  :......:...:..|..  ..::|..:..|.:..:|    |:.|.:|.|....|::..
Mouse   430 EGNDR--YEGYCVELAAEIAKHVG--YSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAV 490

  Fly   281 TPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLW 345
            .|...:..|...:.............|.:.|..:......||:|....:|.......|...|:|:
Mouse   491 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 555

  Fly   346 MI-------FHLERHWMQRCLDFIPS-------LLSSCLISFGAACIQGSYLMPKSAGGRLA--- 393
            ::       :|.|.  .:...|...|       :.:|...|.||...||..:.|:|..||:.
Mouse   556 LVSRFSPYEWHSEE--FEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 618

  Fly   394 --FIAVMLTSFLMYNYYTSIVVSTLLGSPVRS--NIRTIQQLADSSLDVGFDTVPFTKTYLVSSP 454
              |..:::.|....|....:.|..:: ||:.|  ::....::|..:|:.|     .||.:.   .
Mouse   619 WWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLEAG-----STKEFF---R 674

  Fly   455 RPDIRSLYKQKVESKRDPNSVWL-SPEEGVIRVRDQPG-FVYTSEASFMYHFVEKHYLPREISDL 517
            |..|....|.....|....||:: :.|||:||||...| :.|..| |.|..::|:    |:..|.
Mouse   675 RSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLE-STMNEYIEQ----RKPCDT 734

  Fly   518 NEIILRPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSK-QSRFF------------SKTKLH 568
            .::....:|..||: ....|..|..:....:::.|.|:..| :::::            ||.|..
Mouse   735 MKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTS 799

  Fly   569 TFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW-ARYAKKKFS--TIIPQ 621
            ..|.|.|        |.:|..|:....||:|:.::|.|: :|...|:..  .:|||
Mouse   800 ALSLSNV--------AGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQ 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	49/202 (24%)
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	45/221 (20%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	81/400 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907