DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and GRIN3B

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_619635.1	Gene:	GRIN3B / 116444	HGNCID:	16768	Length:	1043	Species:	Homo sapiens

Alignment Length:	408	Identity:	80/408 - (19%)
Similarity:	138/408 - (33%)	Gaps:	120/408 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 RSHCQVKEYLSELHLRPRLQHRMDLSSVT---------FRLAALVSVLPINSSEEELLEFLNSDR 224
            |:...|..|.|.|:|...:..|..:||.|         ..|.|:..:|.::|....|...:..|:
Human   608 RNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDK 672

  Fly   225 DSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWS--VQDAFGG---------------AIGMLT 272
            .  .:.:|.|.:..:.|..:  ||:...:|..:..  ::.:|..               .:.|||
Human   673 T--FEELSGIHDPKLHHPAQ--GFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLT 733

  Fly   273 NESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRT--------------PHNAGI------- 316
            ::..:|  ..|:...:.|.|      :....|.|...|              |.|:.:
Human   734 SDPPKL--NAFIMDKSLLDY------EVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEF 790

  Fly   317 ----KAAVFLEPFMPSVWFAF--AGLLIFA--GVLLWMIFHLERHWMQRCLDFIPSLLSSCLISF 373
                |::.|:: .:...|:..  .|..:||  ..|...|:|....::..||....:||||
Human   791 ISRYKSSGFID-LLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSS----- 849

  Fly   374 GAACIQGSYLMPKSAGGRLAFIAVMLTSFLMYNYYTSIVVSTLLGS--PVRSNIRTIQQLADSSL 436
                      :.:.|..|||...:...|.|.|..:||..:...|.:  |..|...|.:  |:.|
Human   850 ----------LGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAE--AEPS- 901

  Fly   437 DVGFDTVPFTKTYLVSSPRPDIRSLYKQKVES------KRDPNSVWLSPEEGVIRVRDQPGFVYT 495
                              .|::....:|:.:.      ||...:|   .:|..:|...:|..|..
Human   902 ------------------GPEVEQQQQQQDQPTAPEGWKRARRAV---DKERRVRFLLEPAVVVA 945

  Fly   496 SEASFMYHFVEKHYLPRE 513
            .||.     .|....|||
Human   946 PEAD-----AEAEAAPRE 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	43/198 (22%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	37/212 (17%)
		Lig_chan	576..842	CDD:278489	46/246 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740