DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75c and GRIN3A

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	735	Identity:	154/735 - (20%)
Similarity:	253/735 - (34%)	Gaps:	230/735 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VFNLLEINLSNL-------MVFHC--WSIKEAFPLVEMLNQNGIFSQYI-----DVQNPDNLANV 61
            :.:.|:|.|.::       ::|.|  .||:..|   |:..|.|:....:     |.||.:.|
Human   307 LLSFLQIQLESIKNSTPTVVMFGCDMESIRRIF---EITTQFGVMPPELRWVLGDSQNVEEL--- 365

  Fly    62 HKEYLDSDLVRLG-----VFLDLGCDKAELVTNQSSRARLYNQNLHWL------LYDEAGNFTKL 115
            ..|.|...|:..|     ||.....|..|||....:.|.:....|..:      :..|..|.|..
Human   366 RTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSG 430

  Fly   116 TQL--------FEGANLSLNADVTYVSREDEERFI---LHDVYNK------GSHLGGKLNITVD- 162
            ..|        |.|.:.|:....:.:...:...||   .||...|      ||..|||  |.:|
Human   431 QYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGK--IVMDY 493

  Fly   163 ----QTLQCNRSHCQVKEYLSELHLR-----------------------------PRLQHRMDLS 194
                :..|.:::|.|   :.|:||||                             |.......|.
Human   494 GIWPEQAQRHKTHFQ---HPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLD 555

  Fly   195 SVTFRLAALVSVLPINSSE----------EELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGFK 249
            |:...|.:....:||...:          |::.|.:|.|.|.:                 |:|..
Human   556 SLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLY-----------------IVGDG 603

  Fly   250 LHYIW-CGTWSVQDAFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPH- 312
            .:..| .|.|:      |.:|.|...:|.:..|.|  |.|        |.::|   |..|.:|.
Human   604 KYGAWKNGHWT------GLVGDLLRGTAHMAVTSF--SIN--------TARSQ---VIDFTSPFF 649

  Fly   313 --NAGI-----KAAVFLEPFM-PSVWFAFAGLLIFAGVLLWMIFHLERHW------------MQR 357
              :.||     ..|..:..|| |..|..:.|  ||..:.:..:|.....|            ..:
Human   650 STSLGILVRTRDTAAPIGAFMWPLHWTMWLG--IFVALHITAVFLTLYEWKSPFGLTPKGRNRSK 712

  Fly   358 CLDFIPSLLSSCLISFGAACIQGSYLMPKSAGGRLAFIAVMLTSFLMY--NYYTSIVVSTLLGSP 420
            ...|..:|.....:.||...   :...||...||  |:..:...|.|:  :.||:.:.:.::|..
Human   713 VFSFSSALNICYALLFGRTV---AIKPPKCWTGR--FLMNLWAIFCMFCLSTYTANLAAVMVGEK 772

  Fly   421 VRSNIRTIQ--QLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGV 483
            :...:..|.  :|...|....|.||      ..||....:|..:.:..|..|..| |..:| :||
Human   773 IYEELSGIHDPKLHHPSQGFRFGTV------RESSAEDYVRQSFPEMHEYMRRYN-VPATP-DGV 829

  Fly   484 IRVRDQP----GFVYTSEASFMYHFVEKHYLPREIS---DLNEIILRPESAV--YGM-VHLNSTY 538
            ..:::.|    .|:           ::|..|..|:|   |...:.:....|:  ||: :..||.
Human   830 EYLKNDPEKLDAFI-----------MDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSP- 882

  Fly   539 RQLLTQLQVRMLETGITSKQSRFFSKTKLHTF---------------SNSFVI----QVGMEYAA 584
                           :|:..|...|:.|.|.|               ..||.:    |:|:::.:
Human   883 ---------------LTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFS 932

  Fly   585 PLFISLLVAYFLALLILILE 604
            .||:.|.:.:.|::|..|.|
Human   933 GLFVLLCIGFGLSILTTIGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	48/250 (19%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	46/197 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	36/167 (22%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	93/473 (20%)
		Lig_chan	676..942	CDD:278489	60/307 (20%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		1/2 (50%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830