Protein Alignment Ir75c and Grik4

DIOPT Version :10

• Sequence 1: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 698
• Identity: 134/698 - (19%)
• Similarity: 239/698 - (34%)
• Gaps: 205/698 - (29%)

  Fly     7 YRLIVFNLLEINLS----------NLMVFHCWSIKEAF--PLVEMLNQ----------------- 42
            |...:|..||.:|.          |::.|..::...||  ...:.|||
Mouse   240 YYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPFTGPALS 304

  Fly    43 -----NGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLH 102
                 :.:::....||.    .|..:|        :|| ..|.|..|::
Mouse   305 SALLFDAVYAVVTAVQE----LNRSQE--------IGV-KPLSCGSAQI---------------- 340

  Fly   103 WLLYDEAGNFTKLTQLFEGANLSLNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVDQTLQC 167
            |.......|:.::.:| ||    |...:.:.|:.....:.|                   :.||.
Mouse   341 WQHGTSLMNYLRMVEL-EG----LTGHIEFNSKGQRSNYAL-------------------KILQF 381

  Fly   168 NRSHCQ------VKEYLSELHLRPRLQHRMDLSSVTFRLAALVSV------LPINSSEEELLEFL 220
            .|:..|      |.|.||   :..|| :..::|...|....:|:.      |.:..:.:|:   .
Mouse   382 TRNGFQQIGQWHVAEGLS---MDSRL-YASNISDSLFNTTLVVTTILENPYLMLKGNHQEM---E 439

  Fly   221 NSDRDSH--MDSISRIGNRLIMHTQEILGF--KLHYIWCGTWSVQDAFG---GAIGMLTNESAEL 278
            .:||...  :|.:..:.        |||.|  |:..:..|.:.|.:|.|   |.:|.|....|:|
Mouse   440 GNDRYEGFCVDMLKELA--------EILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADL 496

  Fly   279 CTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPH-NAGIKAAV------------FLEPFMPSVW 330
            ...             .:|..|:...|..|..|. ..||....            ||:||.|.||
Mouse   497 AVA-------------GLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVW 548

  Fly   331 FAFAGLLIFAGVLLWMIFHLERH-WMQ-------RCLDFIP--SLLSSCLISFGAACIQGSYLMP 385
            .......:....:|:::..|..: |..       ||...:.  ||.:|.....|....|||.:.|
Mouse   549 LFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAP 613

  Fly   386 KSAGGRL------AFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLAD-SSLDVGFDTV 443
            ::...|.      ||..::::|      ||:.:.:.|....:...|.::..||| ::::.|....
Mouse   614 RALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHG 672

  Fly   444 PFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKH 508
            ..:.|:..:|.....:.::....  .:.|:....|.|||:.|       |..|..:|:.......
Mouse   673 GSSMTFFQNSRYQTYQRMWNYMY--SKQPSVFVKSTEEGIAR-------VLNSNYAFLLESTMNE 728

  Fly   509 YLPREISDLNEIILRPESAVYGM-VHLNSTYRQ----LLTQLQV---------RMLETGITSKQS 559
            |..:...:|.:|....::..||: :.:.|.:|.    .:.|||.         :..|.|...|:.
Mouse   729 YYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEE 793

  Fly   560 RFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW 607
            ...:|            .:|||....:|:.|:....:|:.:.:||..|
Mouse   794 DHRAK------------GLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	38/196 (19%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	37/217 (17%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	80/408 (20%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956