DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75c and Grik4

DIOPT Version :9

Sequence 1:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	698	Identity:	134/698 - (19%)
Similarity:	239/698 - (34%)	Gaps:	205/698 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YRLIVFNLLEINLS----------NLMVFHCWSIKEAF--PLVEMLNQ----------------- 42
            |...:|..||.:|.          |::.|..::...||  ...:.|||
Mouse   240 YYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPFTGPALS 304

  Fly    43 -----NGIFSQYIDVQNPDNLANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLH 102
                 :.:::....||.    .|..:|        :|| ..|.|..|::
Mouse   305 SALLFDAVYAVVTAVQE----LNRSQE--------IGV-KPLSCGSAQI---------------- 340

  Fly   103 WLLYDEAGNFTKLTQLFEGANLSLNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVDQTLQC 167
            |.......|:.::.:| ||    |...:.:.|:.....:.|                   :.||.
Mouse   341 WQHGTSLMNYLRMVEL-EG----LTGHIEFNSKGQRSNYAL-------------------KILQF 381

  Fly   168 NRSHCQ------VKEYLSELHLRPRLQHRMDLSSVTFRLAALVSV------LPINSSEEELLEFL 220
            .|:..|      |.|.||   :..|| :..::|...|....:|:.      |.:..:.:|:   .
Mouse   382 TRNGFQQIGQWHVAEGLS---MDSRL-YASNISDSLFNTTLVVTTILENPYLMLKGNHQEM---E 439

  Fly   221 NSDRDSH--MDSISRIGNRLIMHTQEILGF--KLHYIWCGTWSVQDAFG---GAIGMLTNESAEL 278
            .:||...  :|.:..:.        |||.|  |:..:..|.:.|.:|.|   |.:|.|....|:|
Mouse   440 GNDRYEGFCVDMLKELA--------EILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADL 496

  Fly   279 CTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPH-NAGIKAAV------------FLEPFMPSVW 330
            ...             .:|..|:...|..|..|. ..||....            ||:||.|.||
Mouse   497 AVA-------------GLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVW 548

  Fly   331 FAFAGLLIFAGVLLWMIFHLERH-WMQ-------RCLDFIP--SLLSSCLISFGAACIQGSYLMP 385
            .......:....:|:::..|..: |..       ||...:.  ||.:|.....|....|||.:.|
Mouse   549 LFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAP 613

  Fly   386 KSAGGRL------AFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLAD-SSLDVGFDTV 443
            ::...|.      ||..::::|      ||:.:.:.|....:...|.::..||| ::::.|....
Mouse   614 RALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHG 672

  Fly   444 PFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKH 508
            ..:.|:..:|.....:.::....  .:.|:....|.|||:.|       |..|..:|:.......
Mouse   673 GSSMTFFQNSRYQTYQRMWNYMY--SKQPSVFVKSTEEGIAR-------VLNSNYAFLLESTMNE 728

  Fly   509 YLPREISDLNEIILRPESAVYGM-VHLNSTYRQ----LLTQLQV---------RMLETGITSKQS 559
            |..:...:|.:|....::..||: :.:.|.:|.    .:.|||.         :..|.|...|:.
Mouse   729 YYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEE 793

  Fly   560 RFFSKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFLALLILILEICW 607
            ...:|            .:|||....:|:.|:....:|:.:.:||..|
Mouse   794 DHRAK------------GLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	49/255 (19%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	37/217 (17%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	80/408 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840