DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and GLR5

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	764	Identity:	150/764 - (19%)
Similarity:	258/764 - (33%)	Gaps:	207/764 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVQLANF---------------------VLDNLV---QSRIGFIVLFHCWQSDESLKFAQQFMKP 43
            ||.|.||                     .||:.:   :|||.:.|.......::.|..|....|.
plant   154 LVDLINFYGWKEVISVYSDDELGRNGVSALDDELYKKRSRISYKVPLSVHSDEKFLTNALNKSKS 218

  Fly    44 IHP-ILVYH----QFVQMRGVLNWSHLELSYMGHTQPTLAI-YVDIKCDQTQDL----------- 91
            |.| :.:.|    ..:::..:..    :|..|.|....||. ::.:..|...|.
plant   219 IGPRVYILHFGPDPLLRIFDIAQ----KLQMMTHEYVWLATDWLSVTLDSLSDKGTLKRLEGVVG 279

  Fly    92 LEEASREQIYNQHYHWLLVGNQS----KLEFYD--------LFGLFNISIDADVSYVKEQIQDNN 144
            |.:...|.:..:|:...|..|:|    .|..||        :..|.|..|:...||.::.:....
plant   280 LRQHIPESVKMEHFTHKLQSNRSMNAYALHAYDTVWMIAHGIEELLNEGINITFSYSEKLLHARG 344

  Fly   145 DSVAYAVHDVYNNGKI------------IGGQLNV-TGSHEMSCD-------------------- 176
            ..:.......:|:|::            |.||:.. :|.:.:.||
plant   345 TKLHLEKIKFFNSGELLLEKLLKVNFTGIAGQVQFGSGRNVIGCDYEIINVNKTDVHTVGFWSKN 409

  Fly   177 ---PFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDD------------ELIR 226
               ..|..:|||   .||::.:.:.|:|.|:..........|...::|.            ..:.
plant   410 GGFSVVAPKTRH---SQKKTSFVSDEKLGDITWPGGGREKPRGWVIADSADPLKIVVPRRVSFVE 471

  Fly   227 FLSQE-NDTHIDSLARF-GFHLTLILRDLLHCKMKFI----------FSDSWSKSD-------VV 272
            |:::| |.:|     |. ||.:.:.:..|     ||:          |.:..|..:       |.
plant   472 FVTEEKNSSH-----RIQGFCIDVFIEAL-----KFVPYSVPYIFEPFGNGHSSPNYNHLIQMVT 526

  Fly   273 GGSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLV 337
            .|...|.|   .|:...||.:.  .:.:......||.     :...|.|......:||:||:..:
plant   527 DGVYDAAV---GDIAIVPSRSK--LVDFSQPYASTGL-----VVVIPANDDNATWIFLRPFTSRL 581

  Fly   338 WYLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPR------ 396
            |.:......:|.|::||..:    |:.:.:|......|.:..|.||       |:|..|
plant   582 WCVVLVSFLVIAVVIWILEH----RINEDFRGPPRRQLSTMLLFSF-------STLFKRNQEDTI 635

  Fly   397 SAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLN 461
            |...||:......:..::...||:.:.|.|....:.|.|..:..|..|.:.:|.:...||..||.
plant   636 SNLARLVMIVWLFLLMVLTASYTANLTSILTVQQLPSAITGIDSLRASEVPIGYQAGTFTLEYLT 700

  Fly   462 YS----RLPEIHLFIKRKIESQTQ-NPELWLPAEQGVLRVRDNPGYVYVF-ETSSGYAYVERYFT 520
            ||    |...:.|....:.|...: .|..|    .||..:.|...|:.:| ...:|:..|...|
plant   701 YSLGMARSRLVPLDSTEEYEKALKLGPTNW----GGVAAIVDELPYIELFLAERTGFKIVGEPF- 760

  Fly   521 AQEICDLNEVLFRPEQLFYTHLH--------RNSTYKELFRLRFLRILETGVYRKQRSYWVHMKL 577
                                 :|        |:|..........|::.||...::.|..|: .|.
plant   761 ---------------------MHRGWGFAFKRDSPLAIDMSTAILKLSETRKLQEIRKKWL-CKT 803

  Fly   578 HCVAQ-NFVITVGMEYVAPLL-LMLICADILVVVILLVELAWKRFFTRH 624
            :|..: |:.......::.... |.|:|..|.|...|:..|...|.|.|:
plant   804 NCAGKSNWNPEPNQLHLKSFKGLYLVCIAITVSAFLVFVLRMIRQFVRY 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	58/287 (20%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	46/265 (17%)
		ANF_receptor	46..396	CDD:279440	46/245 (19%)
		GluR_Plant	458..800	CDD:270404	79/398 (20%)
		Lig_chan	581..832	CDD:278489	59/288 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000