DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75a and grid1a

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	564	Identity:	112/564 - (19%)
Similarity:	212/564 - (37%)	Gaps:	141/564 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 WLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDV-----YNNGKIIGGQLN 166
            |.::....|.....|.||.:...:...|:|:.:|...:.|..:. .||     :::.:.:.|.|.
Zfish   364 WSMLDTIQKGRISGLTGLMDFRSNGANSHVQFEILGTSYSETFG-KDVKRLATWDSDRGLNGSLR 427

  Fly   167 VTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELI----RF 227
                                   :.|:.:|    :..:.|:|.|:: :.|..:..:.::    |:
Zfish   428 -----------------------ENRADHG----MQGITLKVVTLL-EEPFVMVAENILGQPKRY 464

  Fly   228 LSQENDTHIDSLAR-FGFHLTLI-LRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTAD----- 285
            .....|. :|:||: .||...:. :.|..:...:  .:.||:      |.:|.::.:.||
Zfish   465 KGFSIDV-LDALAKILGFKYEMYQVADAKYGSPQ--TNGSWN------GMIGELIGKRADVAISA 520

  Fly   286 LTATPSL--ATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLI 348
            :|.||..  ..:...:||.        .||.|..|.....|.....|.||...||......:.::
Zfish   521 ITITPERENVVDFSKRYLD--------YSVGILMTKTEERLNIFSLLAPFDLAVWACIAAAIPVV 577

  Fly   349 GVLLWITFYMECKRMQK----RWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFL 409
            ||::::...::..|.|.    ........|..|...|.:||...|.......|...|:...:.:|
Zfish   578 GVMVFLLRRVQSVRSQNPPGPHQPASVTTSFQSAIWIVYGAFVQQGGESFMSSMALRIAMGSWWL 642

  Fly   410 ISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLF--- 471
            .:.|:.:.||:.:.:.|..|.:.:.|:|.:.|::             :|.:||..:.|..:|
Zfish   643 FTLIVCSSYTANLAAYLTVSRMDNAIRTFQDLSK-------------QSEINYGTVRESAVFEYF 694

  Fly   472 -IK--RKIESQTQNPELW--------------LPAEQGVLRVRDNPGYVYVFETSSGYAYVERYF 519
             :|  ..:|..:...|||              .||| |:.:|:.:| |.::::    .|.:|...
Zfish   695 RVKGTNPLEQDSTFAELWRTINKNQGQDNSVTSPAE-GIRKVKRDP-YAFLWD----MAVLEYAA 753

  Fly   520 TAQEICDL----NEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETG--VYRKQRSYWVH---- 574
            ...:.|.|    |.:..:...|...|   .|.|::||..:.|.:.|.|  ...||: :|..
Zfish   754 LTDDDCTLVVTGNGMSSKGYGLALQH---GSPYRDLFSQKILDLQEKGDLDILKQK-WWPRKGRC 814

  Fly   575 --------------MKLHCVAQNF-VITVGMEYVAPLLLMLICA 603
                          ::||..|..| ::..|:     ||..|:.|
Zfish   815 DLDKHAEPQTEGRALRLHSFAGVFCILAAGL-----LLACLVAA 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	65/314 (21%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	11/60 (18%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	87/412 (21%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740