Protein Alignment Ir75a and Grid2

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 119/633 - (18%)
• Similarity: 247/633 - (39%)
• Gaps: 171/633 - (27%)

  Fly    64 HLELSYMGHTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYH--------------WLLVGNQS 114
            ::|:|       .|.||      .|..||..|..:::.::.:|              |  .|.:|
  Rat   319 NMEIS-------NLYIY------DTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPW--QGGRS 368

  Fly   115 KLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSC-DPF 178
            .||.....|:..::.|.:...     ...|.:|.:.:... |.|:.:|     .|..::.| :|.
  Rat   369 MLETIKKGGVNGLTGDLEFGE-----NGGNPNVHFEILGT-NYGEELG-----RGVRKLGCWNPV 422

  Fly   179 VCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELI----RFLSQENDTHIDSL 239
                |....||..:....|   :..|||||.||: :.|..:..:.::    ::.....|. :|:|
  Rat   423 ----TGLNGSLTDKKLENN---MRGVVLRVVTVL-EEPFVMVSENVLGKPKKYQGFSIDV-LDAL 478

  Fly   240 ARF-GFHLTLILRDLLHCKMKFIFSD----------SWSKSDVVGGSVGAVVDQTAD-----LTA 288
            :.: ||:..:           ::..|          :|:      |.||.:|.:.||     ||.
  Rat   479 SNYLGFNYEI-----------YVAPDHKYGSPQEDGTWN------GLVGELVFKRADIGISALTI 526

  Fly   289 TPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVF--LQPFSPLVWYLFGGVLSLIGVL 351
            ||.  .|..:.:.:..::  :...|.:.|.....    |:|  |.||...:|....|.:.|:|:|
  Rat   527 TPD--RENVVDFTTRYMD--YSVGVLLRRAEKTV----DMFACLAPFDLSLWACIAGTVLLVGLL 583

  Fly   352 LWITFYMECKRMQKRWRLDYLPSLLSTFLIS-----FGAACIQSSSLIPRSAGGRLIYFALFLIS 411
            :::..::...|:|       :.|:.||.|.:     :|:...|...:...:...|::..|.:|.:
  Rat   584 VYLLNWLNPPRLQ-------MGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFA 641

  Fly   412 FIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPF----TKSYLNYSRLPEIHLFI 472
            .|:.:.||:.:.:.|..:.::|.|::::.|::.:      .:|:    ..:...:.|:..::.|.
  Rat   642 LIVISSYTANLAAFLTITRIESSIQSLQDLSKQT------DIPYGTVLDSAVYQHVRMKGLNPFE 700

  Fly   473 KRKIESQTQNPELW-------------LPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEI 524
            :..:.||     :|             |.::.|:.:|:.. .|.:|::.:           ..|.
  Rat   701 RDSMYSQ-----MWRMINRSNGSENNVLESQAGIQKVKYG-NYAFVWDAA-----------VLEY 748

  Fly   525 CDLNEVLFRPEQLFYT------------HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKL 577
            ..:|:    |:..|||            .|...|.|:::|..|.|.:.::|.....:..|.....
  Rat   749 VAIND----PDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNG 809

  Fly   578 HCVAQNFVI------TVGMEYVAPLLLMLICADILVVVILLVELAWKR 619
            .|...:.|.      .:.::.:|.:..:|....:|..:|.::|..|.|
  Rat   810 QCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSR 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	52/305 (17%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		9/38 (24%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	26/139 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	81/426 (19%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740