Protein Alignment Ir75a and Grid1

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_077354.1
• Gene: Grid1 / 79219
• RGDID: 68366
• Length: 1009
• Species: Rattus norvegicus
• Alignment Length: 789
• Identity: 151/789 - (19%)
• Similarity: 282/789 - (35%)
• Gaps: 255/789 - (32%)

  Fly     4 VQLANFVLDNLVQSRIGFIVLFHCWQSDESLKFAQQFMKPIHPI-----------LVYHQFVQMR 57
            |:|.:.:|..:.:.|....|:|  :.|:..::..|.|:.....:           .:.|.|..:
  Rat   147 VRLNDVMLRLVTELRWQKFVMF--YDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSL- 208

  Fly    58 GVLNWSHLELSYMGHTQPTLAIYVDIKCDQ-TQDLLEEASREQIYNQHYHWLLVGNQ-SKLEFYD 120
                ::.::...:...:.||...:.:...| ....:.||....:.::..||:.|..: |..|..|
  Rat   209 ----FTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILD 269

  Fly   121 L----------------------------FGLFNISIDADVSYVKEQIQDNN----DSV---AYA 150
            |                            ..:.::..|....|: :.:|.:|    |||   |.|
  Rat   270 LVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYL-QMLQISNLYLYDSVLMLANA 333

  Fly   151 VH-------------------------------DVYNNGKIIGGQLNVTGSHEM---SCDPFV-- 179
            .|                               |....|.|.|    :||..|.   |.:|:|
  Rat   334 FHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG----LTGVMEFREDSSNPYVQF 394

  Fly   180 -----------CRRTRHLS----------SLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDE 223
                       .:..|.|:          |||:| ..|:|  |..:.|:|.||: :.|..:..:.
  Rat   395 EILGTTYSETFGKDMRKLATWDSEKGLNGSLQER-PMGSR--LQGLTLKVVTVL-EEPFVMVAEN 455

  Fly   224 LI----RFLSQENDTHIDSLAR-FGFHLTLI------LRDLLHCKMKFIFSDSWSKSDVVGGSVG 277
            ::    |:.....|. :|:||: .||...:.      ....||       :.||:      |.:|
  Rat   456 ILGQPKRYKGFSIDV-LDALAKALGFKYEIYQAPDGRYGHQLH-------NTSWN------GMIG 506

  Fly   278 AVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIFR---TPHNAGL-------RGDVF--L 330
            .::.:.|||.             :|||..|....||..|.   ..::.|:       :..:|  .
  Rat   507 ELISKRADLA-------------ISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLF 558

  Fly   331 QPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQK--RWRLDYLPSLLSTFLISFGAACIQSSSL 393
            .||...||......:.::|||:::...::..|.|.  :.|.....:|.|...|.:||...|....
  Rat   559 APFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWIVYGAFVQQGGES 623

  Fly   394 IPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKS 458
            ...|...|::..:.:|.:.|:.:.||:.:.:.|..|.:.|.::|.:.|::.     ||
  Rat   624 SVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDSPVRTFQDLSKQ-----LE------- 676

  Fly   459 YLNYSRLPE--IHLFIKRK----IESQTQNPELWL--------------PAEQGVLRVRDNPGYV 503
             ::|..:.:  ::.:.:.|    :|..:...|||.              |:| |:.:.:.. .|.
  Rat   677 -MSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSE-GIRKAKKG-NYA 738

  Fly   504 YVFETSSGYAYVERYFTAQEICDL----NEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETG- 563
            ::::.    |.||......:.|.:    |.:..:...:...|   .|.|::||..|.|.:.:||
  Rat   739 FLWDV----AVVEYAALTDDDCSVTVIGNSISSKGYGIALQH---GSPYRDLFSQRILELQDTGD 796

  Fly   564 -VYRKQRSYWVH------------------MKLHCVAQNF-VITVGMEYVAPLLLMLICADILVV 608
             ...||: :|.|                  :|||..|..| ::.:|        |:|.|
  Rat   797 LDVLKQK-WWPHTGRCDLTSHSSAQTDGKSLKLHSFAGVFCILAIG--------LLLAC------ 846

  Fly   609 VILLVELAW 617
            ::..:||.|
  Rat   847 LVAALELWW 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	26/142 (18%)
Grid1	NP_077354.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		52/303 (17%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	45/289 (16%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	85/420 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960