DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and grin2ab

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	771	Identity:	138/771 - (17%)
Similarity:	248/771 - (32%)	Gaps:	286/771 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QQFMKPIHPILVYHQFVQ--MRGVL---------NWSHLELSYMGHTQPTLAIYVDIKC--DQTQ 89
            |:|:..:. :.|.|.||:  ::.|:         :.:|::|..:  ..|.:.:|    |  |:..
Zfish   170 QEFIATVR-VTVDHSFVRWDLQSVVTLDGVGEPEDRAHVQLKRI--QSPVILLY----CSKDEAA 227

  Fly    90 DLLEEASREQIYNQHYHW----LLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYA 150
            .::|||....:....:.|    |..||...:......|:.:::.|.....::.::||....::.|
Zfish   228 LVMEEARSLGLTGAGFVWIVPSLTTGNLEHIPEAFPAGMISVTYDEWDYPLETRLQDAVGIISSA 292

  Fly   151 VHDVY-NNGKIIGGQLNVTG-SHEMSCDPFVCRRTRHLSSLQKRSK--------YGNREQLTDVV 205
            ...:: ..|:|..|..:..| |.:....|...|  |::..:....|        |....:|..:|
Zfish   293 AAAMFREEGRIPDGTASCYGQSEKPEVPPSALR--RYMMGVNLGGKDHSFMDDGYQVNPKLVVIV 355

  Fly   206 LRV-------------------------------------ATVVT--QRPLTLSDDELI------ 225
            |..                                     .::||  :||..:.||..|
Zfish   356 LNTEREWEKMGRWENHSLRLKFPVWPRYNSFGDMDADENHLSIVTLEERPFVIVDDVDILTGTCM 420

  Fly   226 ------RFLSQENDTH------------IDSL------ARFGFHLTLILRDLLHCKMKFIFSDSW 266
                  |...::|.|.            ||.|      .:|.:.|.|:... .|.|.   .::.|
Zfish   421 RNSVPCRKHIKDNTTEGSYVKKCCKGFCIDILKKIARNVKFTYDLYLVTNG-KHGKK---INNVW 481

  Fly   267 SKSDVVGGSVGAVVDQTADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDV 328
            :      |.||.||.:.|.:........|.|   :.:....:|||.  ||.:.|:  |..:....
Zfish   482 N------GMVGEVVYKKAVMAVGSLTINEERSEAIDFSVPFVETGI--SVMVSRS--NGTVSPSA 536

  Fly   329 FLQPFSPLVW---------------YLFGGVLSL------------------IGVLLWITFYMEC 360
            ||:|||..||               :||..:..|                  ||..:|:.
Zfish   537 FLEPFSASVWVMMFVMLLIVTAIAVFLFEFISPLGFNRNLAQGKDPHGPSFTIGKAVWLL----- 596

  Fly   361 KRMQKRWRLDYLPSL--------LSTFLISFGAACIQSSSLIPRSAGGRLIYFA-LFLISFIMYN 416
                  |.|.:..|:        .|.|::|..|                  :|| :||.|
Zfish   597 ------WGLVFNNSVPVQNPRGTTSKFIVSVWA------------------FFAVIFLAS----- 632

  Fly   417 YYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNYS------------------ 463
             ||:.:.:.::......::            .||....|...| :||
Zfish   633 -YTANLAAFMIQEEFVDQV------------TGLSDRKFQSPY-SYSPPFRFGTVPNGSTERNIR 683

  Fly   464 -RLPEIHLFIKRKIESQTQNPELWLPAEQGVLRV-------------RDNP------GYVYVFET 508
             ..|.:|.::.:  ..||...:..:..:.|.|..             ||:.      |..|:|.|
Zfish   684 KNYPAMHQYMVK--YHQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIGSGYIFAT 746

  Fly   509 SSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWV 573
             :||...                          :.:.|.:|.|..|..|.|:..|...:..:.|:
Zfish   747 -TGYGIA--------------------------MQKGSYWKRLVDLAILGIIGDGEMEELEAQWL 784

  Fly   574 HMKLHCVAQNFVIT--VGMEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLTF 627
            ....| ..:|.|::  :.::.:|.:..||..|    :.:.|:...|:..|...|.:
Zfish   785 TGICH-NEKNEVMSSQLDVDNMAGVFYMLAAA----MALSLITFVWEHLFYWRLRY 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	56/347 (16%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	38/220 (17%)
		ANF_receptor	48..358	CDD:279440	38/196 (19%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	90/488 (18%)
		Lig_chan	544..816	CDD:278489	57/353 (16%)
		NMDAR2_C	827..1445	CDD:287527	2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930