Protein Alignment Ir75a and grin2aa

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 675
• Identity: 116/675 - (17%)
• Similarity: 215/675 - (31%)
• Gaps: 236/675 - (34%)

  Fly    39 QFMKPIHPILVYHQFVQMRGVLNWSHLELSYM--GH-TQPTLAIYVDIKCDQTQDLLEEASREQI 100
            |..|...|....|:::..   :.|...:||:.  |: ..|.|.:.|
Zfish   320 QMEKTKLPPSALHKYMMN---VTWDGKDLSFTEDGYQVHPKLVVIV------------------- 362

  Fly   101 YNQHYHWLLVG---NQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIG 162
            .|:...|..:|   |||....|.::..||...||:.        |:|
Zfish   363 LNKDREWEKMGKWENQSLTLKYPVWPRFNSFGDAET--------DDN------------------ 401

  Fly   163 GQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRF 227
             .|.:....|   .|||.              ..|.|:||...:|.:....:.   :.|:
Zfish   402 -HLTIVTLEE---KPFVI--------------VENVERLTGTCMRNSVPCRKH---IKDN----- 440

  Fly   228 LSQENDTHIDSLARFGFHLTLILRDLLHCKMKF----IFSDSWSK--SDVVGGSVGAVVDQTADL 286
            .::...|:|....: ||.:.::.:...:.|..:    :.:....|  ::|..|.||.||::.|.:
Zfish   441 TTEGGGTYIKKCCK-GFCIDILKKIARNVKFTYDLYLVTNGKHGKKINNVWNGMVGEVVNKKAVM 504

  Fly   287 TATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLI 348
            ........|.|   :.:....:|||.  ||.:.|:  |..:....||:|||..||.:...:|.|:
Zfish   505 AVGSLTINEERSEVIDFSVPFVETGI--SVMVSRS--NGTVSPSAFLEPFSASVWVMMFVMLLLV 565

  Fly   349 GVLLWITF----------------------YMECKRMQKRWRLDYLPSL--------LSTFLISF 383
            ..:....|                      :...|.:...|.|.:..|:        .|.|::|.
Zfish   566 TAMAVFMFEYISPLGFNRNLAQGKDPHGPSFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSV 630

  Fly   384 GAACIQSSSLIPRSAGGRLIYFA-LFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLT 447
            .|                  :|| :||.|      ||:.:.:.::......::
Zfish   631 WA------------------FFAVIFLAS------YTANLAAFMIQEEFVDQV------------ 659

  Fly   448 VGLEPLPFTKSYLNYS-------------------RLPEIHLFIKRKIESQTQNPELWLPA---- 489
            .||....|...| :||                   ..|::|.::.:..::...:..:.|..
Zfish   660 TGLSDKKFQSPY-SYSPPFRFGTVPNGSTERNIRKNYPDMHQYMVKYHQTGVNDALVSLKTGKLD 723

  Fly   490 ---------------EQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY 539
                           ::|...|....||::   .::||...
Zfish   724 AFIYDAAVLNYMAGRDEGCKLVTIGSGYIF---ATTGYGIA------------------------ 761

  Fly   540 THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLIC 602
              |.:.|.:|....|..|.|:..|...:..:.|:....| ..:|.|::  :.::.:|.:..||..
Zfish   762 --LQKGSLWKRPVDLAILAIIGDGEMEELEAQWLTGICH-NEKNEVMSSQLDVDNMAGVFYMLAT 823

  Fly   603 ADILVVVILLVELAWKRFFTRHLTF 627
            |    :.:.|:...|:..|...|.:
Zfish   824 A----MGLSLITFVWEHLFYWRLRY 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	49/336 (15%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	18/90 (20%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	83/514 (16%)
		NMDAR2_C	836..1460	CDD:313729	2/9 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830