Protein Alignment Ir75a and grin2bb

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 738
• Identity: 126/738 - (17%)
• Similarity: 224/738 - (30%)
• Gaps: 302/738 - (40%)

  Fly    75 PTLAIYVDIKC--DQTQDLLEEASREQIYNQHYHW----LLVGNQSKLEFYDLFGLFNISIDADV 133
            |.:.:|    |  ::...:.|.|....:....|.|    |:.|:...:......||.::|.|...
Zfish   300 PVILLY----CTKEEATTIFEVAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPTGLISVSYDEWD 360

  Fly   134 SYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEM---SCDPFVCRRTRHLSSLQKRSKY 195
            ..::.:::|....:|.|...:..:          .|.|.:   .|         |.:..:|.||.
Zfish   361 YGLEARVRDAVAIIAMATSTMMLD----------RGPHTLLKSGC---------HGAPDKKGSKS 406

  Fly   196 GNREQLTDVVLRVATVVT--QRPLTLSDDE-------LIRFLSQEN------------------- 232
            ||..:    |||....||  .|.|:.|:|.       :|..|::|.
Zfish   407 GNPNE----VLRYLMNVTFEGRNLSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMKYHV 467

  Fly   233 ----DTHIDSLARFGFHLTLI--------------------LRDLLHCK---------------- 257
                :.:.|:..|...||:::                    :|:.:.|:
Zfish   468 WPRFELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYI 532

  Fly   258 ------------------MKFIF--------------SDSWSKSDVVGGSVGAVVDQTADLTATP 290
                              :||.:              :.:|:      |.||.||.:.|.:....
Zfish   533 KRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHGKKINGTWN------GMVGEVVLKNAHMAVGS 591

  Fly   291 SLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLL 352
            ....|.|   :.:....||||.  ||.:.|:  |..:....||:|||..||.:...:|.::..:.
Zfish   592 LTINEERSEVIDFSVPFIETGI--SVMVSRS--NGTVSPSAFLEPFSADVWVMMFVMLLIVSAVA 652

  Fly   353 WITF-------YMEC---------------KRMQKRWRLDYLPSL--------LSTFLISFGAAC 387
            ...|       |..|               |.:...|.|.:..|:        .|..::|..|
Zfish   653 VFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA-- 715

  Fly   388 IQSSSLIPRSAGGRLIYFA-LFLIS-------FIMYNYYTSVVVSSLLS----------SP---- 430
                            :|| :||.|       |::...|...|..  ||          ||
Zfish   716 ----------------FFAVIFLASYTANLAAFMIQEEYVDQVTG--LSDKKFQHPNDFSPPFRF 762

  Fly   431 -----------VKSKIKTMRQLAES-----------SLTVG-LEPLPFTKSYLNYSRLPEIHLFI 472
                       :::..|.|.....|           ||..| |:...:..:.|||
Zfish   763 GTVPNGSTERNIRNNYKEMHSYMTSFHQKNVNEALHSLKSGKLDAFIYDAAVLNY---------- 817

  Fly   473 KRKIESQTQNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQL 537
                         ....::|...|....||::   .::||...
Zfish   818 -------------MAGRDEGCKLVTIGSGYIF---ATTGYGIA---------------------- 844

  Fly   538 FYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLML 600
                :.::|.:|....|..|::...|...:..:.|:....| ..:|.|::  :.::.:|.:..||
Zfish   845 ----IQKDSGWKRAVDLAILQLFGDGEMEELEALWLTGICH-NEKNEVMSSQLDVDNMAGVFYML 904

  Fly   601 ICADILVVVILLVE--LAWK-RF 620
            ..|..|.::..:.|  ..|: ||
Zfish   905 GAAMALSLITFIAEHLFYWQLRF 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	53/342 (15%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	37/196 (19%)
		ANF_receptor	138..442	CDD:279440	34/168 (20%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	76/482 (16%)
		Lig_chan	636..908	CDD:278489	53/344 (15%)
		NMDAR2_C	919..1770	CDD:287527	3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830