Protein Alignment Ir75a and grik2

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001410875.1
• Gene: grik2 / 556013
• ZFINID: ZDB-GENE-080414-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 688
• Identity: 137/688 - (19%)
• Similarity: 251/688 - (36%)
• Gaps: 189/688 - (27%)

  Fly     4 VQLANFVLDNLVQSRIGFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELS 68
            |.:..|.:.|...|::..|:  ..|    |::..|...||...:|  ..|:.....|.:..:.:.
Zfish   274 VNMTGFRILNTENSQVSSII--EKW----SMERLQAPPKPDSGLL--DGFMTTDAALMYDAVHVV 330

  Fly    69 YMGHTQPTLAIYVDIKCDQTQ---------DLLEEASREQIYNQHYHWLLVGNQSKLEFYDLFGL 124
            .:...|........::|::.:         .|::||          ||  .|...::.|....||
Zfish   331 AVAVQQSPQITVSSLQCNRHKPWRFGNRFMTLIKEA----------HW--DGLTGRINFNRTNGL 383

  Fly   125 FNISIDADVSYVKEQ------IQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRT 183
             ....|.||..:||:      ..|....:     ::..|.|  |...|||.|
Zfish   384 -RTDFDLDVISLKEEGLEKIGTWDPASGL-----NMTENQK--GKTANVTDS------------- 427

  Fly   184 RHLSSLQKRSKYGNREQLTDVVLRVATVV---TQRPLTLSDD------ELIRFLSQENDTHIDSL 239
                       ..||..:...:|....|:   :.:||..:|.      :|:|.|:        ::
Zfish   428 -----------LSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYCVDLLRELA--------AI 473

  Fly   240 ARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLK---YL 301
            ..||:.|.|:.......:.:  .|..|:      |.|..::|..|||...|...|..|.|   :.
Zfish   474 LGFGYELRLVEDGRYGAQDE--SSGQWN------GMVRELMDHKADLAVAPLAITYVREKVIDFS 530

  Fly   302 SAIIETGFFRSVCIFRTPH--NAGLRGDVFLQPFSPLVW-YLFGGVLSLIGVLLWITFYMECKRM 363
            ...:..|.  |: ::|.|:  |.|:..  ||.|.||.:| |:....|.:..||..|..:...:
Zfish   531 KPFMTLGI--SI-LYRKPNGTNPGVFS--FLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYE-- 588

  Fly   364 QKRWRLDYLP--------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFL 409
               |   |.|              :||::|....||...|.|.|:|::...|::     :|.|.:
Zfish   589 ---W---YNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLII 647

  Fly   410 ISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLA-ESSLTVGLEPLPFTKSYLNYSRLPEIHLFIK 473
            ||     .||:.:.:.|....::|.|.:...|| ::.:..|:.....|.::           |.|
Zfish   648 IS-----SYTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTF-----------FKK 696

  Fly   474 RKIE---------SQTQNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNE 529
            .||.         |..::..:....|:|:.||..: .|.::.|:::    :|  |..|..|:|.:
Zfish   697 TKISTYDKMWEFMSSRRHSVMVKSIEEGIERVLTS-DYAFLMESTT----IE--FVTQRNCNLTQ 754

  Fly   530 VLFRPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF--------- 584
            :....:...| ......|.|::...:..|::.|.|            |||.:.:.:
Zfish   755 IGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEG------------KLHMMKEKWWRGNGCPEE 807

  Fly   585 ----VITVGMEYVAPLLLMLICADILVVVILLVELAWK 618
                ...:|::.:..:.::|....:|.|.:.:.|..:|
Zfish   808 ENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	23/126 (18%)
grik2	NP_001410875.1	PBP1_iGluR_Kainate	37..414	CDD:380605	30/165 (18%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	94/433 (22%)