DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75a and grid2

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	495	Identity:	96/495 - (19%)
Similarity:	190/495 - (38%)	Gaps:	130/495 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 YGNREQLTD---------VVLRVATVVTQRPLTLSDDELI----RFLSQENDTHIDSLARF-GFH 245
            :|....|||         |||||.||: :.|..:..:.::    ::.....|. :|:||.: ||.
Zfish   423 HGLNGTLTDRKLENNMRGVVLRVVTVL-EEPFVMVSENVLGKPKKYQGFSIDV-LDALANYLGFK 485

  Fly   246 LTLILRDLLHCKMKFIFSD----------SWSKSDVVGGSVGAVVDQTAD-----LTATPSLA-- 293
            ..:           ::..|          :|:      |.:|.:|.:.||     ||.||...
Zfish   486 YEI-----------YVAPDHKYGSQQADGTWN------GLIGELVFKRADVGLSALTITPERESV 533

  Fly   294 ---TEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWIT 355
               |...:.|...::.....|:|.:|           ..|.||...:|....|.:.|:|.|:::.
Zfish   534 VDFTTRYMDYSVGVLLRKAERTVDMF-----------ACLAPFDLSLWACIAGTVLLVGTLVYLL 587

  Fly   356 FYMECKRMQKRWRLDYLPSLLSTFLIS-----FGAACIQSSSLIPRSAGGRLIYFALFLISFIMY 415
            .::...|:.       :.|:.||.|.:     :|:...|...:...:...|::....:|.:.|:.
Zfish   588 NWLNPPRLP-------MGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVI 645

  Fly   416 NYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQT 480
            :.||:.:.:.|..|.:::.|::::.||:.:      .||: .:.|:.:        :..::.|:.
Zfish   646 SSYTANLAAFLTISRIENSIQSLQDLAKQT------DLPY-GTVLDSA--------VYDQVRSKG 695

  Fly   481 QNP--------ELWL-------------PAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEI 524
            .||        ::|.             .:::|:.:|:.. .:.:|::.    |.:|......|.
Zfish   696 MNPFERDPMYSQMWRMINRTGGAENNVEESKEGIRKVKYG-RFAFVWDA----AVLEYVAINDED 755

  Fly   525 CDL----NEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFV 585
            |.|    |.|..|...:...|   .|.|:::|..|.|.:.:.|.....:..|......|...:.|
Zfish   756 CSLYTVSNNVADRGYGMAMQH---GSPYRDIFSQRILELQQNGDMDILKLKWWPRDSPCDLYSPV 817

  Fly   586 IT------VGMEYVAPLLLMLICADILVVVILLVELAWKR 619
            .|      :.:...|.:..:|....:|..:|..||..|.|
Zfish   818 GTRKSGSALDIHSFAGVFFVLAAGVVLSCLIATVETWWTR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	53/301 (18%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	1/3 (33%)
		ANF_receptor	42..404	CDD:279440
		PBP2_iGluR_delta_2	440..806	CDD:270449	81/425 (19%)
		Lig_chan	568..841	CDD:278489	53/302 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740