Protein Alignment Ir75a and gria1b

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_991293.1
• Gene: gria1b / 403044
• ZFINID: ZDB-GENE-020125-2
• Length: 917
• Species: Danio rerio
• Alignment Length: 698
• Identity: 133/698 - (19%)
• Similarity: 252/698 - (36%)
• Gaps: 183/698 - (26%)

  Fly    41 MKPIHPILVYHQFVQM------RGVLNWSHLELSYMGHTQPTLAIYVDIKCDQTQDLLEEASREQ 99
            :|..|.||....|:.:      :|..|.:..:|  |.:|.||::..:       ||.||..|::
Zfish   222 LKNYHYILANLGFLDLNLTEFRKGGANVTGFQL--MNYTNPTVSRTI-------QDWLEFDSKD- 276

  Fly   100 IYNQHYHWLLVGNQSKLEFYDLFGLFNISIDA--------------------------------- 131
                     |...:.:|::........:::.|
Zfish   277 ---------LKSPKRRLKYTGALTYDGVTVMATAFQNLRKQRIDISRRGNAGECLANPPAPWGQG 332

  Fly   132 -DVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKY 195
             |:....:|:|..    ....|..:|:.   |.:.|.|    :|...|.....:.:....:|.||
Zfish   333 IDIQRALQQVQFE----GLTGHVQFNDK---GHRTNFT----VSVMEFGPSGPKKVGYWNQREKY 386

  Fly   196 GNREQLTDVV---------LRVATVVTQRP---LTLSDDELIRFLSQENDTH----IDSLARFGF 244
            .:....::::         ..|.|.:.:.|   |..:.::|:     .||.:    ::..|....
Zfish   387 VSTATYSNMLNETFGLQNRTYVVTTILEAPYVMLKKNHEQLV-----GNDKYEGYCVELAAEIAK 446

  Fly   245 HLTLILRDLLHCKMKFIFSDS----WSKSDVVGGSVGAVVDQTADLTATP---SLATEGRLKYLS 302
            |:....|..|....|:...|:    |:      |.||.:|...||:...|   :|..|..:.:..
Zfish   447 HVGYSYRLELVGDGKYGARDAETMMWN------GMVGELVYGKADVAVAPLTITLVREEVIDFSK 505

  Fly   303 AIIETGFFRSVCIFR-TPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKR 366
            ..:..|.  |:.|.: |....|:..  ||.|.:..:|...  |.:.|||.  :..::..:.....
Zfish   506 PFMSLGI--SIMIKKPTKSKPGVFS--FLDPLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPYE 562

  Fly   367 WRLD------------YLPS-----------------------------LLSTFLISFGAACIQS 390
            |..|            ..||                             :.::...|.||...|.
Zfish   563 WHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQG 627

  Fly   391 SSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKS--KIKTMRQLAESSLTV 448
            ..:.|||..||::     :|.|.:||....|....:.|..:: ||::|  .:....::|..:|..
Zfish   628 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDG 691

  Fly   449 GLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWL-PAEQGVLRVRDNPG-YVYVFETSSG 511
            |     .||.:...|:   |.:|.|.....::..|.::: ..::||:|||.:.| |.|:.|::
Zfish   692 G-----STKEFFRRSK---IAVFEKMWSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLEST-- 746

  Fly   512 YAYVERYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHM 575
               :..|...::.||..:|....:...| ....:.|..:....|..|::.|.|:..|.::.|.:.
Zfish   747 ---MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD 808

  Fly   576 KLHC-----VAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWK 618
            |..|     .:::....:.:..||.:..:||....|.:::.|||..:|
Zfish   809 KGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYK 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/119 (23%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..390	CDD:380613	33/197 (17%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	90/440 (20%)