Protein Alignment Ir75a and GluRIA

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 817
• Identity: 146/817 - (17%)
• Similarity: 284/817 - (34%)
• Gaps: 269/817 - (32%)

  Fly    20 GFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELSYMGHTQPTLA------ 78
            |:..:.:.:.|.:.|...||..:.:.|.....:...::.:.|.: :.:.:: ||...|.
  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVT-MAIEFL-HTLEDLGRFSKKR 229

  Fly    79 IYVDIKCDQTQDLLEEASRE-QIYNQHYHWLLVG----NQSKLEFYDLFGLFNIS----IDADVS 134
            |.:|...:..::::.:..|: ::..:.||:||.|    |....:..: ||..||:    :|::..
  Fly   230 IVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVE-FGAINITGFRIVDSNRR 293

  Fly   135 YVKE------------QIQDNN------------------DSVAYAVHDVYNNGKII-------- 161
            .|::            |.|..|                  |:| :.:.:.:|  :|:
  Fly   294 AVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAV-FVLVEAFN--RILRKKPDQFR 355

  Fly   162 ---------GG--QLNVTGSHEMS----CD-------PF--------VCRRTR--HLSSLQKRSK 194
                     ||  ..:.||::|.|    |:       |:        |.|:..  .||...:..:
  Fly   356 SNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE 420

  Fly   195 YGNREQLTDVVLRVATVVT-QRPLTLSDDE-LIRFLS-----------------QENDTHID--- 237
            .|.|...|..|:.::...| |:.....||. |:...|                 ..|.|:|.
  Fly   421 DGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSL 485

  Fly   238 ------SLARFGFHLTLILRDLL--HCK---------------MKFIFSDSWSKSDVVG-----G 274
                  ||.::.:..:|:..|..  :||               ::.:...::...:...     |
  Fly   486 LEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDG 550

  Fly   275 SVGAVVDQTADLTATPSLATEGRLKY-----------LSAIIETGFFRSVCIFRTPHNAGLRGDV 328
            .||.::.:.||:..:....|..|.:.           :|.:|:....::..:|.
  Fly   551 MVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFS----------- 604

  Fly   329 FLQPFSPLVWYLFGGVLSLIG---VLLWITFYMECK-RMQKRWRLD------------------- 370
            ||.|.|..:|  ...:||.:|   ||.::|.:...: |:.:|.:.|
  Fly   605 FLNPLSQEIW--ISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQ 667

  Fly   371 -YLP-------SLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLL 427
             ::|       ::|::|..|..|...|...:.|.|..||:.....:..:.|:.:.||:.:.:.|.
  Fly   668 AHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLT 732

  Fly   428 SSPVKSKIKTMRQLA------ESSLTVGLEPLPFTKS----------YLNYSRLPEIHLFIKRKI 476
            ...:.:.|||...|.      ..:|..|.....|.:|          |:|.::...:|.:
  Fly   733 VERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTY----- 792

  Fly   477 ESQTQNPELWLPAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYT 540
                         ::|:.|||.:.| |..:.|:..     ..|..|:..||..:|
  Fly   793 -------------DEGIRRVRQSKGKYALLVESPK-----NEYVNARPPCDTMKV---------- 829

  Fly   541 HLHRN-------------STYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT---VG 589
              .||             |..::......|.:.|.|...:.|:.|...|..|.......|   :.
  Fly   830 --GRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELS 892

  Fly   590 MEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLT 626
            :..||.:..:||...:|.|::.::|     ||.|:.|
  Fly   893 LSNVAGIYYILIGGLLLAVIVAIME-----FFCRNKT 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	24/140 (17%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	53/294 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	79/449 (18%)
		Lig_chan	610..906	CDD:459656	63/332 (19%)