Protein Alignment Ir75a and gria3b

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_938174.1
• Gene: gria3b / 368416
• ZFINID: ZDB-GENE-030616-53
• Length: 883
• Species: Danio rerio
• Alignment Length: 823
• Identity: 143/823 - (17%)
• Similarity: 272/823 - (33%)
• Gaps: 258/823 - (31%)

  Fly     8 NFVLDNLVQSRIGFIVLFHCWQSDESL--------------------KFAQQFMKPIHPILVYHQ 52
            |:.:|||..|....:....|.|....:                    .....|:.|.:||....|
Zfish    62 NYNVDNLESSNSFSVTHAFCSQFSRGVYAIFGFYDKKSMNTLTSFCGALHTSFVTPSYPIDSDVQ 126

  Fly    53 FV-QMRGVL---------------------------------------NWSHLELSYMGHTQP-- 75
            || |||..|                                       ||.....|....|.|
Zfish   127 FVIQMRPPLKGAVLSLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVANNWQVTARSVGSITDPQE 191

  Fly    76 ------------TLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVGNQSKLEFYDLFGLFNIS 128
                        .....:|.:.|:...:||:.......::.||:::..          .|..|||
Zfish   192 FRRIIEEMDRRQEKRYLIDCEVDRINVILEQVVTLGKNSRGYHYIIAN----------LGFTNIS 246

  Fly   129 ID------ADVS----------------------------------------------------- 134
            :|      |::|
Zfish   247 LDKVFLGGANISGFQIINPENLVVQQFLQRWDRLDEREFPEAKNTPLKYTSALSYDAILVIAEAF 311

  Fly   135 -YVKEQIQD-----------NNDSVAYAVH-DVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHL 186
             |::.|..|           .|.:|.::.. |:....|::..| .:||:  :..|.| .|||.:.
Zfish   312 RYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQ-GMTGN--IQFDSF-GRRTNYT 372

  Fly   187 SSLQKRSKYGNR--------EQLTDVVLR--------------VATVVTQRPLTLSDDELIRFLS 229
            ..:.:....|.|        |:..:::.:              |.|.:.:.|..         :.
Zfish   373 IDVYEMKTGGPRKIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAPYV---------MY 428

  Fly   230 QENDTHIDSLARF-GFHLTLILRDLLHCKMKFIFS--------------DSWSKSDVVGGSVGAV 279
            ::|..|::...:: |:.:.|......|..:|:..|              .||:      |.||.:
Zfish   429 KKNHMHLEGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPETKSWN------GMVGEL 487

  Fly   280 VDQTADLTATP---SLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLF 341
            |...||:...|   :|..|..:.:....:..|.  |:.| :.|..:......||.|.:..:|...
Zfish   488 VYGRADIAVAPLTITLVREEVIDFSKPFMSLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI 549

  Fly   342 GGVLSLIGVLLWITFYMECKRMQKRWRLDYLP---------------SLLSTFLISFGAACIQSS 391
              |.:.|||.  :..::..:.....|:||...               .:.::...|.||...|..
Zfish   550 --VFAYIGVS--VVLFLVSRFSPYEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGC 610

  Fly   392 SLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLA-ESSLTVGLEPLPF 455
            .:.|||..||::....:..:.|:.:.||:.:.:.|....:.|.|::...|| ::.:..|......
Zfish   611 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGS 675

  Fly   456 TKSYLNYSRLPEIHLFIKRKIESQTQNPELWLPAE---QGVLRVRDNPG-YVYVFETSSGYAYVE 516
            ||.:...|::.     :..|:.|..::.|..:.|:   .||.|||.:.| :.::.|::     :.
Zfish   676 TKEFFRRSKIA-----VYEKMWSYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLEST-----MN 730

  Fly   517 RYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHC- 579
            .|...::.||..:|....:...| ....:.|..:....|..|::.|.|:..|.::.|.:.|..|
Zfish   731 EYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795

  Fly   580 ----VAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWK 618
                .:::....:.:..||.:..:|:....|.:::.|:|..:|
Zfish   796 SGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYK 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	57/291 (20%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	54/347 (16%)
		ANF_receptor	36..379	CDD:279440	51/330 (15%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	81/413 (20%)
		Lig_chan	544..824	CDD:278489	57/293 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840