Protein Alignment Ir75a and clumsy

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 150/745 - (20%)
• Similarity: 282/745 - (37%)
• Gaps: 183/745 - (24%)

  Fly    12 DNLVQSR-IGFIVLFHCWQS-------DESLKFAQQFM---KPI-HPILV--------YHQFVQM 56
            |||:.|: :..||....|:|       |:.|:..|..:   :|| :|..|        :..|::
  Fly   137 DNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLK- 200

  Fly    57 RGVLNWSHLELSYMGHTQPTLAIYVDIKC--DQTQDLLEEASREQIYNQHYH-WLLVGNQSKLEF 118
                   .::||    |...|.::    |  |....:|::|:..::..::.. ::.:.:...::|
  Fly   201 -------EIKLS----TDNCLILH----CAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDF 250

  Fly   119 YDLFGLFNISIDADVSYVKEQIQDNND-SVAYAVHDVYNNGKIIGGQLNVTGS------------ 170
            .:|.|     ::|:::.|:  :.|.:| .|...|||.....|..|....|..:
  Fly   251 GELSG-----VEANITTVR--LMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDA 308

  Fly   171 --------------HEMSCDPFVCRR-------TRHLSSLQKRS-----------KYGNREQLT- 202
                          .|::.....|||       .|.:..::.||           :.|.|...|
  Fly   309 VWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTL 373

  Fly   203 -------DVVLRVATVVTQRPL-TLSDDELIR---------------------FLS----QENDT 234
                   |..|.:||......| .|:|||...                     ||:    ||.:.
  Fly   374 RFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEI 438

  Fly   235 HIDSLARFGFHLTLI--LRDLLHCKMKFIFS------------DSWSKSDVVGGSVGAVVDQTAD 285
            ...:....|:.:.||  :..:|:.|.:|..|            .:|.      |.|..::|..||
  Fly   439 LTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWD------GIVRQLIDGNAD 497

  Fly   286 LTATPSLATEGRLKYLSAIIETGFFRSV---CIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSL 347
            |.......|..|.:   |:..|..|.::   .:|..|.........||.|||..||...|.....
  Fly   498 LGICDLTMTSSRRQ---AVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLF 559

  Fly   348 IGVLLWITFYM---------ECKRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLI 403
            |.:||:....|         .||..::   ::.:.|:::|..:|.|:...|...::|::|..||:
  Fly   560 ISLLLFALARMAPDDWENPHPCKEPEE---VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLV 621

  Fly   404 YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQL-AESSLTVGLEPLPFTKSYLNYSRLPE 467
            ....:..:.:|.|.||:.:.:.|.:|...:.|.:...| |:|.:..|...   ..|.:.:.|...
  Fly   622 TGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMA---GGSTMGFFRDSN 683

  Fly   468 IHLFIKRKIESQTQNPELWLPA-EQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEV 530
            ...:.|.....::.:|.::... ::||.||:.... |.::.|:::....|||.      |||.::
  Fly   684 FSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK------CDLVQI 742

  Fly   531 -LFRPEQLFYTHLHRNSTYKELFRLRFLRILETG-VYRKQRSYW--VHMKLHCVAQN----FVIT 587
             .:...:.:...:..||.|::......|::.|.| :...:|.:|  :|...:|...:    ....
  Fly   743 GGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPE 807

  Fly   588 VGMEYVAPLLLMLICADILVVVILLVELAW 617
            :|:|.|..:.|:|....:..:|:...|..|
  Fly   808 LGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	23/120 (19%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	53/282 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	82/393 (21%)