DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75a and Grik3

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	100/486 - (20%)
Similarity:	189/486 - (38%)	Gaps:	124/486 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 GNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHC---- 256
            |....:||.:...:.:||    ||.::..:.|  :::|..:....||..:...:|::|.|.
  Rat   422 GRGPNVTDSLTNRSLIVT----TLLEEPFVMF--RKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480

  Fly   257 -KMKFIFSDSWSKSDVVG---GSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSV---C 314
             :::.:....:...|..|   |.|..::|..|||...|...|..|.|   ||..:..|.::   .
  Rat   481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREK---AIDFSKPFMTLGVSI 542

  Fly   315 IFRTPHNAGLRGDVFLQPFSPLVW------YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP 373
            ::|.|:........||.|.||.:|      ||  ||..::.|:...:.|        .| .|..|
  Rat   543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYL--GVSCVLFVIARFSPY--------EW-YDAHP 596

  Fly   374 ------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSV 421
                        :||::|....|:...|.|.|:|::...|:|     :|.|.:||     .||:.
  Rat   597 CNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS-----SYTAN 656

  Fly   422 VVSSLLSSPVKSKIKTMRQLAE------SSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQT 480
            :.:.|....::|.|.:...||:      .::..|.....|.||.:  |...::..|:..|..:..
  Rat   657 LAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKI--STFEKMWAFMSSKPSALV 719

  Fly   481 QNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEV----------LFRPE 535
            :|      .|:|:.|.. ...|..:.|:::    :| |.| |..|:|.::          :..|
  Rat   720 KN------NEEGIQRTL-TADYALLMESTT----IE-YIT-QRNCNLTQIGGLIDSKGYGIGTP- 770

  Fly   536 QLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-------------VIT 587
                    ..|.|::...:..|::.|..            |||.:.:.:             ...
  Rat   771 --------MGSPYRDKITIAILQLQEED------------KLHIMKEKWWRGSGCPEEENKEASA 815

  Fly   588 VGMEYVAPLLLMLICADILVVVILLVELAWK 618
            :|::.:..:.::|....:|.|::.:.|..:|
  Rat   816 LGIQKIGGIFIVLAAGLVLSVLVAVGEFIYK 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	60/317 (19%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	91/428 (21%)
		Lig_chan	564..832	CDD:278489	60/319 (19%)
		Glutamate binding	690..692		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740