Protein Alignment Ir75a and Grik1

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001104587.1
• Gene: Grik1 / 29559
• RGDID: 2732
• Length: 949
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 154/760 - (20%)
• Similarity: 274/760 - (36%)
• Gaps: 249/760 - (32%)

  Fly    21 FIVLFHCWQSDESLKFAQQFMKPIHPILV------YHQF------------------VQMRG--V 59
            |.|:|.|     |.:.|.:.:|.|  :.:      ||.|                  |.|.|  :
  Rat   225 FYVIFDC-----SHETAAEILKQI--LFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRL 282

  Fly    60 LN------------WS--HLE---------LSYMGHTQPTL---AIYVDIKCDQTQDLLEEASRE 98
            ||            ||  .|:         |..|..|:..|   |:|:..........|..:|.:
  Rat   283 LNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQ 347

  Fly    99 QIYNQHYHWLL-------------VGNQSKLEFYDLFGLFNISIDADVSYVKEQ-IQDNNDSVAY 149
              .::|..|.|             .|...::.|....|| ....|.|:..:||: .:..:..|:.
  Rat   348 --CHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGL-RKDFDLDIISLKEEGTEKASGEVSK 409

  Fly   150 AVHDVYNNGKIIG-----GQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQ---LTDVVL 206
            .::.|:   |.||     ..||:|.                          |||::   :||.:.
  Rat   410 HLYKVW---KKIGIWNSNSGLNMTD--------------------------GNRDRSNNITDSLA 445

  Fly   207 RVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHC-----KMKFIFSDSW 266
            ....:||    |:.::..:.:  :::|..:....||..:...:|::|.:.     .:|.:....:
  Rat   446 NRTLIVT----TILEEPYVMY--RKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKY 504

  Fly   267 SKSDVVG---GSVGAVVDQTADLTATPSLATEGRLK---YLSAIIETGFFRSVCIFRTPH--NAG 323
            ...:..|   |.|..::|..|||...|...|..|.|   :....:..|.  |: ::|.|:  |.|
  Rat   505 GAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI--SI-LYRKPNGTNPG 566

  Fly   324 LRGDVFLQPFSPLVW-YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP-------------- 373
            :..  ||.|.||.:| |:....|.:..||..|..:...:     |   |.|
  Rat   567 VFS--FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYE-----W---YNPHPCNPDSDVVENNF 621

  Fly   374 SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKS 433
            :||::|....||...|.|.|:|::...|::     :|.|.:||     .||:.:.:.|....::|
  Rat   622 TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVERMES 681

  Fly   434 KIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPE---IHLFIKRKIE---------SQTQNPELW 486
            .|.:...||:.           ||  :.|..:.:   :..|.|.||.         |..|...|.
  Rat   682 PIDSADDLAKQ-----------TK--IEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALV 733

  Fly   487 LPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY---THLHRNSTY 548
            ..:::|:.||. ...|..:.|::|    :|  :..|..|:|.::....:...|   |.:  .|.|
  Rat   734 KNSDEGIQRVL-TTDYALLMESTS----IE--YVTQRNCNLTQIGGLIDSKGYGVGTPI--GSPY 789

  Fly   549 KELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-------------VITVGMEYVAPLLLML 600
            ::...:..|::.|.|            |||.:.:.:             ...:|:|.:..:.::|
  Rat   790 RDKITIAILQLQEEG------------KLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFIVL 842

  Fly   601 ICADILVVVILLVELAWK----------------RFFTRH-LTFH 628
            ....:|.|.:.:.|..:|                ||:.|: :.||
  Rat   843 AAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSRLRFYFRNKVRFH 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/131 (21%)
Grik1	NP_001104587.1	PBP1_iGluR_Kainate	38..431	CDD:380605	45/218 (21%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	91/426 (21%)