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Protein Alignment Ir75a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	513	Identity:	112/513 - (21%)
Similarity:	193/513 - (37%)	Gaps:	137/513 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SKYGNREQLTDVV--LRVATVVTQRPLTLSDD----------ELIRFLSQENDTH---------- 235
            |:||...|..|..  |.||| :.:||..:.:.          :.:...||.|.||
Human   417 SRYGRFLQPVDDTQHLTVAT-LEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE 480

  Fly   236 --------IDSLAR------FGFHLTLILRDLLHCKMKFIFSDSWSKSD-VVGGSVGAVVDQTAD 285
                    ||.|.|      |.:.|.|:... .|.|          |.| |..|.:|.|..|.||
Human   481 KRCCKGFCIDILKRLAHTIGFSYDLYLVTNG-KHGK----------KIDGVWNGMIGEVFYQRAD 534

  Fly   286 LTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVW-YLFGGVLS 346
            :........|.|   :.:....:|||.  ||.:.|:  |..:....||:|:||.|| .:|...|:
Human   535 MAIGSLTINEERSEIVDFSVPFVETGI--SVMVARS--NGTVSPSAFLEPYSPAVWVMMFVMCLT 595

  Fly   347 LIGVLLWITFYMECKRMQKRWRLDYLPSLL-------STFLISFGA----ACIQSSSL---IPRS 397
            ::.|.::|..|:.        .:.|..||.       |||.|....    |.:.::|:   .||.
Human   596 VVAVTVFIFEYLS--------PVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRG 652

  Fly   398 AGGRL--IYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESS----------LTVGL 450
            ...::  :.:|.|.:.|:.  .||:.:.:.::.   :..:.|:..|::..          |..|.
Human   653 TTSKIMVLVWAFFAVIFLA--SYTANLAAFMIQ---EEYVDTVSGLSDRKFQRPQEQYPPLKFGT 712

  Fly   451 EPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYV 515
            .|...|:..:. |..|::|.::.|..:.:         .|:.:.:::......::::     |.|
Human   713 VPNGSTEKNIR-SNYPDMHSYMVRYNQPR---------VEEALTQLKAGKLDAFIYD-----AAV 762

  Fly   516 ERYFTAQ-EICDLNEVLFRPEQLFYT-----HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVH 574
            ..|...: |.|.|  |.....::|.|     .||:.|.:|....|..|:.|...........|
Human   763 LNYMARKDEGCKL--VTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLW-- 823

  Fly   575 MKLHCVAQNFVITV-----GMEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLTF 627
              |..:..|..|.|     .::.:|.:..||:.|    :.:.|:..||:     ||.:
Human   824 --LSGICHNDKIEVMSSKLDIDNMAGVFYMLLVA----MGLSLLVFAWE-----HLVY 870

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.