Protein Alignment Ir75a and GRIN2C

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 803
• Identity: 148/803 - (18%)
• Similarity: 272/803 - (33%)
• Gaps: 283/803 - (35%)

  Fly    23 VLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQ-MRGVLNWSH----------LELSYMG---HT 73
            |||...:..:...||  .:..:||  .:..|:: :|.|.:.||          |||...|   .|
Human   152 VLFKVLEEYDWSAFA--VITSLHP--GHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRART 212

  Fly    74 Q--------PTLAIYVDIKC--DQTQDLLEEASREQIYNQHYHWLL----VGNQSKLEFYDLFGL 124
            |        |....|    |  ::.:.|..||::..:....:.||:    :|:..........||
Human   213 QRLLRQLDAPVFVAY----CSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGL 273

  Fly   125 FNISIDADVSYVKEQIQDNNDSVAYAVHDVYNN---------------GKIIGGQ-------LNV 167
            .::..::....::::::|....:|...|..:..               |.:...:       |||
Human   274 ISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNV 338

  Fly   168 T-GSHEMSCDP--FVCRRTRHLSSLQKRSKYGNREQLTDVVLR-------------------VAT 210
            | ...:.|..|  ::.:.|..:.:|       ||.:|.::|.|                   :..
Human   339 TWEGRDFSFSPGGYLVQPTMVVIAL-------NRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQP 396

  Fly   211 VVTQRPLTLSDDELIRFL--------------------SQENDTH-----------------IDS 238
            ||..|.||::..|...|:                    .|.|.|.                 ||.
Human   397 VVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDI 461

  Fly   239 L------ARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGR 297
            |      .:|.:.|.|:.......:::.:    |:      |.:|.|..:.||:........|.|
Human   462 LKKLARVVKFSYDLYLVTNGKHGKRVRGV----WN------GMIGEVYYKRADMAIGSLTINEER 516

  Fly   298 ---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVW---------------YLF--- 341
               :.:....:|||.  ||.:.|:  |..:....||:|:||.||               ::|
Human   517 SEIVDFSVPFVETGI--SVMVARS--NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYF 577

  Fly   342 ---------------GGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLSTFLISFGAACIQSS 391
                           ||....||..:|:.           |.|.:..|:           .|::
Human   578 SPVSYNQNLTRGKKSGGPAFTIGKSVWLL-----------WALVFNNSV-----------PIEN- 619

  Fly   392 SLIPRSAGGRL--IYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAE-SSL---TVGL 450
               ||....::  :.:|.|.:.|:.  .||:.:.:.::.   :..|.|:..|:: .||   ..|:
Human   620 ---PRGTTSKIMVLVWAFFAVIFLA--SYTANLAAFMIQ---EQYIDTVSGLSDKKSLHLENTGV 676

  Fly   451 EPLPFTKSYLNYSRLPE----------------------------IHL--FIKRKIESQTQNPEL 485
            ....|.....:|.:.|:                            .|:  |.:|.:|....:.::
Human   677 AWTAFKTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM 741

  Fly   486 WLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQ-EICDLNEVLFRPEQLFYT-----HLHR 544
            ...| |.|.|..|    .::::     |.|..|...: |.|.|  |.....::|.|     .:.:
Human   742 GSEA-QPVPRKLD----AFIYD-----AAVLNYMAGKDEGCKL--VTIGSGKVFATTGYGIAMQK 794

  Fly   545 NSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQN-----FVITVGMEYVAPLLLMLICAD 604
            :|.:|....|..|:.|..|..:|..:.|    |..:.||     ....:.::.:|.:..||:.|
Human   795 DSHWKRAIDLALLQFLGDGETQKLETVW----LSGICQNEKNEVMSSKLDIDNMAGVFYMLLVA- 854

  Fly   605 ILVVVILLVELAWKRFFTRHLTF 627
               :.:.|:..||:     ||.:
Human   855 ---MGLALLVFAWE-----HLVY 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	28/152 (18%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	46/246 (19%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	89/489 (18%)
		NMDAR2_C	866..>941	CDD:463148	2/4 (50%)