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Protein Alignment Ir75a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	447	Identity:	81/447 - (18%)
Similarity:	158/447 - (35%)	Gaps:	124/447 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 IDSLARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGR--- 297
            |....:|.:.|.|:... .|.|.   .:.:|:      |.:|.||.:.|.:........|.|
Human   468 ISKSVKFTYDLYLVTNG-KHGKK---INGTWN------GMIGEVVMKRAYMAVGSLTINEERSEV 522

  Fly   298 LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITF------ 356
            :.:....||||.  ||.:.|:  |..:....||:|||..||.:...:|.::..:....|
Human   523 VDFSVPFIETGI--SVMVSRS--NGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV 583

  Fly   357 -YMEC---------------KRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLI-- 403
             |..|               |.:...|.|.:..|:           .:|:    |:....:::
Human   584 GYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSV-----------PVQN----PKGTTSKIMVS 633

  Fly   404 YFALFLISFIMYNYYTSVVVSSLLSSPVKSKI-----KTMRQLAESS--LTVGLEPLPFTKSYL- 460
            .:|.|.:.|:.  .||:.:.:.::......::     |..::..:.|  ...|..|...|:..:
Human   634 VWAFFAVIFLA--SYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR 696

  Fly   461 -NYSRLPEIHLFIKRKIESQTQNPELWLPA-------------------EQGVLRVRDNPGYVYV 505
             ||:   |:|.::.:..:....:..|.|..                   ::|...|....|.|:
Human   697 NNYA---EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVF- 757

  Fly   506 FETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRS 570
              .|:||...                          :.::|.:|....|..|::...|...:..:
Human   758 --ASTGYGIA--------------------------IQKDSGWKRQVDLAILQLFGDGEMEELEA 794

  Fly   571 YWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLICADILVVVILLVE-LAWKRFFTRH 624
            .|:....| ..:|.|::  :.::.:|.:..||..|..|.::..:.| |.:.:|  ||
Human   795 LWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQF--RH 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.