Protein Alignment Ir75a and GRIN2A

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 104/595 - (17%)
• Similarity: 199/595 - (33%)
• Gaps: 176/595 - (29%)

  Fly   124 LFNISIDA-DVSYVKEQIQDNNDSVAYAVHD-----VYNNGKIIGGQLNVTG---SHEMSCDPFV 179
            :.|::.|. |:|:.:|         .|.||.     |.|..:    :....|   :|.:|....|
Human   390 MVNVTWDGKDLSFTEE---------GYQVHPRLVVIVLNKDR----EWEKVGKWENHTLSLRHAV 441

  Fly   180 CRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIR-------FLSQENDTH-- 235
            ..|.:..|..:....:     |:.|.|..|..|....:....:..:|       |:...|.|:
Human   442 WPRYKSFSDCEPDDNH-----LSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEG 501

  Fly   236 -----------IDSL------ARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQT 283
                       ||.|      .:|.:.|.|:... .|.|         ..::|..|.:|.||.|.
Human   502 MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG-KHGK---------KVNNVWNGMIGEVVYQR 556

  Fly   284 ADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVL 345
            |.:........|.|   :.:....:|||.  ||.:.|:  |..:....||:|||..||.:...:|
Human   557 AVMAVGSLTINEERSEVVDFSVPFVETGI--SVMVSRS--NGTVSPSAFLEPFSASVWVMMFVML 617

  Fly   346 SLIGVLLWITF-YME---CKRMQKRWRLDYLPSL-------LSTFLISFGAACIQSSSLIPRSAG 399
            .::..:....| |..   ..|...:.:..:.||.       |...|:...:..:|:    |:...
Human   618 LIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQN----PKGTT 678

  Fly   400 GRLI--YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNY 462
            .:::  .:|.|.:.|:.  .||:.:.:.::......::            .||....|.:.: :|
Human   679 SKIMVSVWAFFAVIFLA--SYTANLAAFMIQEEFVDQV------------TGLSDKKFQRPH-DY 728

  Fly   463 S-------------------RLPEIHLFIKRKIESQTQNPELWLPA------------------- 489
            |                   ..|.:|.::.:..:...::..:.|..
Human   729 SPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGR 793

  Fly   490 EQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRL 554
            ::|...|....||::   .::||...                          |.:.|.:|....|
Human   794 DEGCKLVTIGSGYIF---ATTGYGIA--------------------------LQKGSPWKRQIDL 829

  Fly   555 RFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLICADILVVVILLVELAW 617
            ..|:.:..|...:..:.|:....| ..:|.|::  :.::.:|.:..||..|    :.:.|:...|
Human   830 ALLQFVGDGEMEELETLWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAA----MALSLITFIW 889

  Fly   618 KRFFTRHLTF 627
            :..|...|.|
Human   890 EHLFYWKLRF 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	44/318 (14%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740