DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75a and GRIK4

DIOPT Version :10

Sequence 1:NP_649012.2 Gene:Ir75a / 39982 FlyBaseID:FBgn0036757 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_055434.2 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:693 Identity:140/693 - (20%)
Similarity:252/693 - (36%) Gaps:204/693 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LDNLVQSRI---GFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELSYMGH 72
            :|:||..|:   ||.:.      ::|..|.|:|.:.::.              :|.. ...::..
Human   255 MDSLVDDRVNILGFSIF------NQSHAFFQEFAQSLNQ--------------SWQE-NCDHVPF 298

  Fly    73 TQPTL-------AIYVDIKCDQTQDLLEE-------ASREQIYNQHYHWLLVGNQSKLEFYDLFG 123
            |.|.|       |:|..:...|..:..:|       ....||: ||...|:    :.|...:|.|
Human   299 TGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIW-QHGTSLM----NYLRMVELEG 358

  Fly   124 LFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSS 188
            |        ..:::...:....:.|..:.....||....||.:|  :..:|.|       .||.:
Human   359 L--------TGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHV--AEGLSMD-------SHLYA 406

  Fly   189 LQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARF-GF------HL 246
                      ..::|.:.....|||    |:.::..:  :.:.|...::...|: ||      .|
Human   407 ----------SNISDTLFNTTLVVT----TILENPYL--MLKGNHQEMEGNDRYEGFCVDMLKEL 455

  Fly   247 TLILRDLLHCKMKFIFSDSWSKSDVVG---GSVGAVVDQTADLTATPSLATEGRLKYLS------ 302
            ..|||  .:.|::.:....:...:..|   |.||.::.:.|||.......|..|.|.:.      
Human   456 AEILR--FNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFM 518

  Fly   303 ----AII-------ETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVW------YL-FGGVLSLIG 349
                :|:       :.|:|.                 ||.||||.||      || ...||.|:.
Human   519 TLGISILYRVHMGRKPGYFS-----------------FLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   350 VLLWITFYMECKRMQKRWRL---DYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLIS 411
            .|....:|......|.|..|   .|  ||.::.....|....|.|::.||:...|.:....:..:
Human   567 RLTPYEWYSPHPCAQGRCNLLVNQY--SLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFT 629

  Fly   412 FIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAE------------SSLTVGLEPLPFTKS-YLNYS 463
            .|:.:.||:.:.:.|....:...|:::..||:            ||:|.      |..| |..|.
Human   630 LIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTF------FQNSRYQTYQ 688

  Fly   464 RLPEIHLFIKRKIESQTQNPELWLPA-EQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDL 527
            |:.. :::.|:        |.:::.: |:|:.||. |..|.::.|::....|.:|.      |:|
Human   689 RMWN-YMYSKQ--------PSVFVKSTEEGIARVL-NSNYAFLLESTMNEYYRQRN------CNL 737

  Fly   528 NEV-----------------LFRPE-QLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVH 574
            .::                 :||.| .|....|..|:      ||..|:          |.:|..
Human   738 TQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENN------RLEILK----------RKWWEG 786

  Fly   575 MKLHCVAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAW 617
            .|......:....:|||.:..:.::|||..|:.:.:.::|..|
Human   787 GKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75aNP_649012.2 Periplasmic_Binding_Protein_Type_2 455..572 CDD:473866 28/136 (21%)
GRIK4NP_055434.2 PBP1_iGluR_Kainate_KA1_2 24..402 CDD:380616 35/189 (19%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 91/434 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.

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