DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75a and GRIK4

DIOPT Version :9

Sequence 1:NP_649012.2 Gene:Ir75a / 39982 FlyBaseID:FBgn0036757 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:693 Identity:140/693 - (20%)
Similarity:252/693 - (36%) Gaps:204/693 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LDNLVQSRI---GFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELSYMGH 72
            :|:||..|:   ||.:.      ::|..|.|:|.:.::.              :|.. ...::..
Human   255 MDSLVDDRVNILGFSIF------NQSHAFFQEFAQSLNQ--------------SWQE-NCDHVPF 298

  Fly    73 TQPTL-------AIYVDIKCDQTQDLLEE-------ASREQIYNQHYHWLLVGNQSKLEFYDLFG 123
            |.|.|       |:|..:...|..:..:|       ....||: ||...|:    :.|...:|.|
Human   299 TGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIW-QHGTSLM----NYLRMVELEG 358

  Fly   124 LFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSS 188
            |        ..:::...:....:.|..:.....||....||.:|  :..:|.|       .||.:
Human   359 L--------TGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHV--AEGLSMD-------SHLYA 406

  Fly   189 LQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARF-GF------HL 246
                      ..::|.:.....|||    |:.::..:  :.:.|...::...|: ||      .|
Human   407 ----------SNISDTLFNTTLVVT----TILENPYL--MLKGNHQEMEGNDRYEGFCVDMLKEL 455

  Fly   247 TLILRDLLHCKMKFIFSDSWSKSDVVG---GSVGAVVDQTADLTATPSLATEGRLKYLS------ 302
            ..|||  .:.|::.:....:...:..|   |.||.::.:.|||.......|..|.|.:.      
Human   456 AEILR--FNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFM 518

  Fly   303 ----AII-------ETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVW------YL-FGGVLSLIG 349
                :|:       :.|:|.                 ||.||||.||      || ...||.|:.
Human   519 TLGISILYRVHMGRKPGYFS-----------------FLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   350 VLLWITFYMECKRMQKRWRL---DYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLIS 411
            .|....:|......|.|..|   .|  ||.::.....|....|.|::.||:...|.:....:..:
Human   567 RLTPYEWYSPHPCAQGRCNLLVNQY--SLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFT 629

  Fly   412 FIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAE------------SSLTVGLEPLPFTKS-YLNYS 463
            .|:.:.||:.:.:.|....:...|:::..||:            ||:|.      |..| |..|.
Human   630 LIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTF------FQNSRYQTYQ 688

  Fly   464 RLPEIHLFIKRKIESQTQNPELWLPA-EQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDL 527
            |:.. :::.|:        |.:::.: |:|:.||. |..|.::.|::....|.:|.      |:|
Human   689 RMWN-YMYSKQ--------PSVFVKSTEEGIARVL-NSNYAFLLESTMNEYYRQRN------CNL 737

  Fly   528 NEV-----------------LFRPE-QLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVH 574
            .::                 :||.| .|....|..|:      ||..|:          |.:|..
Human   738 TQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENN------RLEILK----------RKWWEG 786

  Fly   575 MKLHCVAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAW 617
            .|......:....:|||.:..:.::|||..|:.:.:.::|..|
Human   787 GKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75aNP_649012.2 Lig_chan 337..603 CDD:306551 66/307 (21%)
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 33/180 (18%)
ANF_receptor 43..382 CDD:279440 28/160 (18%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 91/434 (21%)
Lig_chan 547..816 CDD:278489 67/308 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155759
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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