DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75a and GRIK3

DIOPT Version :9

Sequence 1:NP_649012.2 Gene:Ir75a / 39982 FlyBaseID:FBgn0036757 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_000822.2 Gene:GRIK3 / 2899 HGNCID:4581 Length:919 Species:Homo sapiens


Alignment Length:486 Identity:97/486 - (19%)
Similarity:188/486 - (38%) Gaps:124/486 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 GNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHC---- 256
            |....:||.:...:.:||    |:.::..:.|  :::|..:....||..:...:|::|.|.    
Human   422 GRGPNVTDSLTNRSLIVT----TVLEEPFVMF--RKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480

  Fly   257 -KMKFIFSDSWSKSDVVG---GSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSV---C 314
             :::.:....:...|..|   |.|..::|..|||...|...|..|.|   ||..:..|.::   .
Human   481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREK---AIDFSKPFMTLGVSI 542

  Fly   315 IFRTPHNAGLRGDVFLQPFSPLVW------YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP 373
            ::|.|:........||.|.||.:|      ||  ||..::.|:...:.|        .| .|..|
Human   543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYL--GVSCVLFVIARFSPY--------EW-YDAHP 596

  Fly   374 ------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSV 421
                        :||::|....|:...|.|.|:|::...|:|     :|.|.:||     .||:.
Human   597 CNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS-----SYTAN 656

  Fly   422 VVSSLLSSPVKSKIKTMRQLAE------SSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQT 480
            :.:.|....::|.|.:...||:      .::..|.....|.||.:  |...::..|:..|..:..
Human   657 LAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKI--STFEKMWAFMSSKPSALV 719

  Fly   481 QNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEV----------LFRPE 535
            :|      .|:|:.|.. ...|..:.|:::    :|  :..|..|:|.::          :..| 
Human   720 KN------NEEGIQRAL-TADYALLMESTT----IE--YVTQRNCNLTQIGGLIDSKGYGIGTP- 770

  Fly   536 QLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-------------VIT 587
                    ..|.|::...:..|::.|..            |||.:.:.:             ...
Human   771 --------MGSPYRDKITIAILQLQEED------------KLHIMKEKWWRGSGCPEEENKEASA 815

  Fly   588 VGMEYVAPLLLMLICADILVVVILLVELAWK 618
            :|::.:..:.::|....:|.|::.:.|..:|
Human   816 LGIQKIGGIFIVLAAGLVLSVLVAVGEFVYK 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75aNP_649012.2 Lig_chan 337..603 CDD:306551 58/317 (18%)
GRIK3NP_000822.2 PBP1_iGluR_Kainate_GluR5_7 34..417 CDD:107388
ANF_receptor 55..398 CDD:279440
PBP2_iGluR_Kainate_GluR7 433..801 CDD:270441 88/428 (21%)
Lig_chan 564..832 CDD:278489 58/319 (18%)
Glutamate binding. /evidence=ECO:0000250 690..692 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155917
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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