Protein Alignment Ir75a and GRIK2

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_068775.1
• Gene: GRIK2 / 2898
• HGNCID: 4580
• Length: 908
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 120/593 - (20%)
• Similarity: 217/593 - (36%)
• Gaps: 174/593 - (29%)

  Fly    91 LLEEASREQIYNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVY 155
            |::||          ||  .|...::.|....|| ....|.||..:||:..:.
Human   362 LIKEA----------HW--EGLTGRITFNKTNGL-RTDFDLDVISLKEEGLEK------------ 401

  Fly   156 NNGKIIG-----GQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQR 215
                 ||     ..||:|                       .|:.|....:||.:...:.:||
Human   402 -----IGTWDPASGLNMT-----------------------ESQKGKPANITDSLSNRSLIVT-- 436

  Fly   216 PLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDL-----LHCKMKFIFSDSWSKSDVVGGS 275
              |:.::..:.|  :::|..:....||..:...:||:|     ...:::.:....:...|...|.
Human   437 --TILEEPYVLF--KKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQ 497

  Fly   276 ----VGAVVDQTADLTATPSLATEGRLK---YLSAIIETGFFRSVCIFRTPH--NAGLRGDVFLQ 331
                |..::|..|||...|...|..|.|   :....:..|.  |: ::|.|:  |.|:..  ||.
Human   498 WNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI--SI-LYRKPNGTNPGVFS--FLN 557

  Fly   332 PFSPLVW-YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP--------------SLLSTFLI 381
            |.||.:| |:....|.:..||..|..:...:     |   |.|              :||::|..
Human   558 PLSPDIWMYILLAYLGVSCVLFVIARFSPYE-----W---YNPHPCNPDSDVVENNFTLLNSFWF 614

  Fly   382 SFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQL 441
            ..||...|.|.|:|::...|::     :|.|.:||     .||:.:.:.|....::|.|.:...|
Human   615 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVERMESPIDSADDL 674

  Fly   442 AESSLTVGLEPLPFTKSYLNYSRLPE---IHLFIKRKIE---------SQTQNPELWLPAEQGVL 494
            |:.           ||  :.|..:.:   :..|.|.||.         |..:...|....|:|:.
Human   675 AKQ-----------TK--IEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQ 726

  Fly   495 RVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLR 558
            ||..: .|.::.|:::    :|  |..|..|:|.::....:...| ......|.|::...:..|:
Human   727 RVLTS-DYAFLMESTT----IE--FVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQ 784

  Fly   559 ILETGVYRKQRSYWVHMKLHCVAQNF-------------VITVGMEYVAPLLLMLICADILVVVI 610
            :.|.|            |||.:.:.:             ...:|::.:..:.::|....:|.|.:
Human   785 LQEEG------------KLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFV 837

  Fly   611 LLVELAWK 618
            .:.|..:|
Human   838 AVGEFLYK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	26/129 (20%)
GRIK2	NP_068775.1	PBP1_iGluR_Kainate	37..414	CDD:380605	18/81 (22%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	91/425 (21%)