Protein Alignment Ir75a and GRID1

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 789
• Identity: 150/789 - (19%)
• Similarity: 281/789 - (35%)
• Gaps: 255/789 - (32%)

  Fly     4 VQLANFVLDNLVQSRIGFIVLFHCWQSDESLKFAQQFMKPIHPI-----------LVYHQFVQMR 57
            |:|.:.:|..:.:.|....|:|  :.|:..::..|.|:.....:           .:.|.|..:
Human   147 VRLNDVMLRLVTELRWQKFVMF--YDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSL- 208

  Fly    58 GVLNWSHLELSYMGHTQPTLAIYVDIKCDQ-TQDLLEEASREQIYNQHYHWLLVGNQ-SKLEFYD 120
                ::.::...:...:.||...:.:...| ....:.||....:.::..||:.|..: |..|..|
Human   209 ----FTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILD 269

  Fly   121 L----------------------------FGLFNISIDADVSYVKEQIQDNN----DSV---AYA 150
            |                            ..:.::..|....|: :.:|.:|    |||   |.|
Human   270 LVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYL-QMLQISNLYLYDSVLMLANA 333

  Fly   151 VH-------------------------------DVYNNGKIIGGQLNVTGSHEM---SCDPFV-- 179
            .|                               |....|.|.|    :||..|.   |.:|:|
Human   334 FHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG----LTGVMEFREDSSNPYVQF 394

  Fly   180 -----------CRRTRHLS----------SLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDE 223
                       .:..|.|:          |||:| ..|:|  |..:.|:|.||: :.|..:..:.
Human   395 EILGTTYSETFGKDMRKLATWDSEKGLNGSLQER-PMGSR--LQGLTLKVVTVL-EEPFVMVAEN 455

  Fly   224 LI----RFLSQENDTHIDSLAR-FGFHLTLI------LRDLLHCKMKFIFSDSWSKSDVVGGSVG 277
            ::    |:.....|. :|:||: .||...:.      ....||       :.||:      |.:|
Human   456 ILGQPKRYKGFSIDV-LDALAKALGFKYEIYQAPDGRYGHQLH-------NTSWN------GMIG 506

  Fly   278 AVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIFR---TPHNAGL-------RGDVF--L 330
            .::.:.|||.             :|||..|....||..|.   ..::.|:       :..:|  .
Human   507 ELISKRADLA-------------ISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLF 558

  Fly   331 QPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQK--RWRLDYLPSLLSTFLISFGAACIQSSSL 393
            .||...||......:.::|||:::...::..|.|.  :.|.....:|.|...|.:||...|....
Human   559 APFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGES 623

  Fly   394 IPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPFTKS 458
            ...|...|::..:.:|.:.|:.:.||:.:.:.|..|.:.:.|:|.:.|::             :.
Human   624 SVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSK-------------QV 675

  Fly   459 YLNYSRLPE--IHLFIKRK----IESQTQNPELW--------------LPAEQGVLRVRDNPGYV 503
            .::|..:.:  ::.:.:.|    :|..:...|||              .|:| |:.:.:.. .|.
Human   676 EMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSE-GIRKAKKG-NYA 738

  Fly   504 YVFETSSGYAYVERYFTAQEICDL----NEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETG- 563
            ::::.    |.||......:.|.:    |.:..:...:...|   .|.|::||..|.|.:.:||
Human   739 FLWDV----AVVEYAALTDDDCSVTVIGNSISSKGYGIALQH---GSPYRDLFSQRILELQDTGD 796

  Fly   564 -VYRKQRSYWVHM------------------KLHCVAQNF-VITVGMEYVAPLLLMLICADILVV 608
             ...||: :|.||                  |||..|..| ::.:|        |:|.|
Human   797 LDVLKQK-WWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIG--------LLLAC------ 846

  Fly   609 VILLVELAW 617
            ::..:||.|
Human   847 LVAALELWW 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	26/142 (18%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		52/303 (17%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	45/289 (16%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	83/420 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954