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Protein Alignment Ir75a and GRIA4

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	443	Identity:	87/443 - (19%)
Similarity:	182/443 - (41%)	Gaps:	53/443 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 VATVVTQRPLTL--SDDELIRFLSQENDTH----IDSLARFGFHLTLILRDLLHCKMKFIFSDSW 266
            |.|.:.:.|..:  .:.|:.    :.||.:    :|..:....|:.:..:..:....|:...|:.
Human   418 VVTTIMESPYVMYKKNHEMF----EGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDAD 478

  Fly   267 SKSDVVGGSVGAVVDQTADLTATP---SLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDV 328
            :|  :..|.||.:|...|::...|   :|..|..:.:....:..|.  |:.| :.|..:......
Human   479 TK--IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGI--SIMI-KKPQKSKPGVFS 538

  Fly   329 FLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRL-----------DYLPS---LLSTF 379
            ||.|.:..:|...  |.:.|||.  :..::..:.....|..           |..|:   :.::.
Human   539 FLDPLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSL 599

  Fly   380 LISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLA-E 443
            ..|.||...|...:.|||..||::....:..:.|:.:.||:.:.:.|....:.|.|::...|| :
Human   600 WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 664

  Fly   444 SSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWL-PAEQGVLRVRDNPG-YVYVF 506
            :.:..|......||.:...|:   |.::.|.....::..|.::. ...:||.|||.:.| :.::.
Human   665 TEIAYGTLDSGSTKEFFRRSK---IAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLL 726

  Fly   507 ETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRS 570
            |::     :..|...::.||..:|....:...| ....:.|:.:....|..|::.|.||..|.::
Human   727 EST-----MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKN 786

  Fly   571 YWVHMKLHC-----VAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWK 618
            .|.:.|..|     .:::....:.:..||.:..:|:....|.:::.|:|..:|
Human   787 KWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK 839

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.