back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and GRIA3

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	538	Identity:	104/538 - (19%)
Similarity:	208/538 - (38%)	Gaps:	88/538 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEM----SCDPFVCRRTRHLSSL 189
            ||.:.:....|:|....::.:..:....|..|...::.|:||.:.    ..:.||     ..|..
Human   352 IDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV-----PFSDQ 411

  Fly   190 QKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARF-GFHLTLILRDL 253
            |..:...:.|..|.||    |.:.:.|..         :.::|...::...|: |:.:.|.....
Human   412 QISNDSASSENRTIVV----TTILESPYV---------MYKKNHEQLEGNERYEGYCVDLAYEIA 463

  Fly   254 LHCKMKFIFSDSWSKSDVVG---------------GSVGAVVDQTADLTATP---SLATEGRLKY 300
            .|.::|:       |..:||               |.||.:|...||:...|   :|..|..:.:
Human   464 KHVRIKY-------KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDF 521

  Fly   301 LSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQK 365
            ....:..|.  |:.| :.|..:......||.|.:..:|...  |.:.|||.  :..::..:....
Human   522 SKPFMSLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPY 579

  Fly   366 RWRLD---------YLP-------SLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIM 414
            .|.|:         ..|       .:.::...|.||...|...:.|||..||::....:..:.|:
Human   580 EWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 644

  Fly   415 YNYYTSVVVSSLLSSPVKSKIKTMRQLA-ESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIES 478
            .:.||:.:.:.|....:.|.|::...|| ::.:..|......||.:...|:   |.::.|.....
Human   645 ISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSK---IAVYEKMWSYM 706

  Fly   479 QTQNPELWL-PAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-T 540
            ::..|.::. ....||.|||.:.| :.::.|::     :..|...::.||..:|....:...| .
Human   707 KSAEPSVFTKTTADGVARVRKSKGKFAFLLEST-----MNEYIEQRKPCDTMKVGGNLDSKGYGV 766

  Fly   541 HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHC-----VAQNFVITVGMEYVAPLLLML 600
            ...:.|..:....|..|::.|.|:..|.::.|.:.|..|     .:::....:.:..||.:..:|
Human   767 ATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYIL 831

  Fly   601 ICADILVVVILLVELAWK 618
            :....|.:::.|:|..:|
Human   832 VGGLGLAMMVALIEFCYK 849

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.