Protein Alignment Ir75a and GRIA2

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Alignment Length: 677
• Identity: 126/677 - (18%)
• Similarity: 239/677 - (35%)
• Gaps: 182/677 - (26%)

  Fly    79 IYVDIKCDQTQDLLEEASREQIYNQHYHWLLV------GNQSKLEFYDLFGLFNIS----IDADV 133
            :.:|.:.|:..|::::......:.:.||:::.      |:..|::    ||..|:|    :|.|.
Human   207 VILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQ----FGGANVSGFQIVDYDD 267

  Fly   134 SYV------------KEQIQDNNDSVAYAVHDVYN------------------------------ 156
            |.|            ||....:..::.|.....|:
Human   268 SLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLA 332

  Fly   157 --------------------------------NGKIIGGQLNV-----TGSHEMSCDPFVCRRTR 184
                                            |||.|...:|:     .|..::.....|.:...
Human   333 NPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVV 397

  Fly   185 HLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARF-GFHLTL 248
            .|:.|...:.....|..|.||    |.:.:.|..         :.::|...::...|: |:.:.|
Human   398 TLTELPSGNDTSGLENKTVVV----TTILESPYV---------MMKKNHEMLEGNERYEGYCVDL 449

  Fly   249 ILRDLLHCKMKFIFSDSWSKSDVVG---------------GSVGAVVDQTADLTATP---SLATE 295
            ......||..|:       |..:||               |.||.:|...||:...|   :|..|
Human   450 AAEIAKHCGFKY-------KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVRE 507

  Fly   296 GRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMEC 360
            ..:.:....:..|.  |:.| :.|..:......||.|.:..:|...  |.:.|||.  :..::..
Human   508 EVIDFSKPFMSLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVS 565

  Fly   361 KRMQKRWRLDYLP--------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFA 406
            :.....|..:...              .:.::...|.||...|...:.|||..||::     :|.
Human   566 RFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 630

  Fly   407 LFLISFIMYNYYTSVVVSSLLSSPVKS--KIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIH 469
            |.:||....|....:.|..:: ||::|  .:....::|..:|..|     .||.:...|:   |.
Human   631 LIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTEIAYGTLDSG-----STKEFFRRSK---IA 686

  Fly   470 LFIKRKIESQTQNPELWL-PAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLF 532
            :|.|.....::..|.::: ...:||.|||.:.| |.|:.|::     :..|...::.||..:|..
Human   687 VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLEST-----MNEYIEQRKPCDTMKVGG 746

  Fly   533 RPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-----VITVGME 591
            ..:...| ....:.|:.:....|..|::.|.||..|.::.|.:.|..|.|::.     ...:.:.
Human   747 NLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLS 811

  Fly   592 YVAPLLLMLICADILVVVILLVELAWK 618
            .||.:..:|:....|.:::.|:|..:|
Human   812 NVAGVFYILVGGLGLAMLVALIEFCYK 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	28/119 (24%)
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	26/194 (13%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	88/421 (21%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877