Protein Alignment Ir75a and Grin2a

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 118/674 - (17%)
• Similarity: 210/674 - (31%)
• Gaps: 234/674 - (34%)

  Fly    39 QFMKPIHPILVYHQFVQMRGVLNWSHLELSYM--GH-TQPTLAIYVDIKCDQTQDLLEEASREQI 100
            |..||..|:...|||:..   :.|...:||:.  |: ..|.|.:.|
  Rat   323 QAEKPETPLHTLHQFMVN---VTWDGKDLSFTEEGYQVHPRLVVIV------------------- 365

  Fly   101 YNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQL 165
            .|:...|..||   |.|...|                        |:.:||...|.:..
  Rat   366 LNKDREWEKVG---KWENQTL------------------------SLRHAVWPRYKSFS------ 397

  Fly   166 NVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIR---- 226
                    .|:|    ...|||.               |.|..|..|....:....:..:|
  Rat   398 --------DCEP----DDNHLSI---------------VTLEEAPFVIVEDIDPLTETCVRNTVP 435

  Fly   227 ---FLSQENDTH-------------IDSL------ARFGFHLTLILRDLLHCKMKFIFSDSWSKS 269
               |:...|.|:             ||.|      .:|.:.|.|:... .|.|         ..:
  Rat   436 CRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG-KHGK---------KVN 490

  Fly   270 DVVGGSVGAVVDQTADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQ 331
            :|..|.:|.||.|.|.:........|.|   :.:....:|||.  ||.:.|:  |..:....||:
  Rat   491 NVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGI--SVMVSRS--NGTVSPSAFLE 551

  Fly   332 PFSPLVWYLFGGVLSLIGVLLWITF-YME---CKRMQKRWRLDYLPSL-------LSTFLISFGA 385
            |||..||.:...:|.::..:....| |..   ..|...:.:..:.||.       |...|:...:
  Rat   552 PFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNS 616

  Fly   386 ACIQSSSLIPRSAGGRLI--YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTV 448
            ..:|:    |:....:::  .:|.|.:.|:.  .||:.:.:.::......::            .
  Rat   617 VPVQN----PKGTTSKIMVSVWAFFAVIFLA--SYTANLAAFMIQEEFVDQV------------T 663

  Fly   449 GLEPLPFTKSYLNYS-------------------RLPEIHLFIKRKIESQTQNPELWLPA----- 489
            ||....|.:.: :||                   ..|.:|.::.|..:...::..:.|..
  Rat   664 GLSDKKFQRPH-DYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDA 727

  Fly   490 --------------EQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYT 540
                          ::|...|....||::   .::||...
  Rat   728 FIYDAAVLNYKAGRDEGCKLVTIGSGYIF---ATTGYGIA------------------------- 764

  Fly   541 HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLICA 603
             |.:.|.:|....|..|:.:..|...:..:.|:....| ..:|.|::  :.::.:|.:..||..|
  Rat   765 -LQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAA 827

  Fly   604 DILVVVILLVELAWKRFFTRHLTF 627
                :.:.|:...|:..|...|.|
  Rat   828 ----MALSLITFIWEHLFYWKLRF 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	19/154 (12%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	22/112 (20%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	80/476 (17%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		2/20 (10%)
		NMDAR2_C	839..1464	CDD:463148	3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464