Protein Alignment Ir75a and Grin3a

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 555
• Identity: 105/555 - (18%)
• Similarity: 188/555 - (33%)
• Gaps: 177/555 - (31%)

  Fly    57 RGVLNWSHLELSYMGHTQPTLAIYVDIKCD--QTQDLLEEASREQIYNQHYHWLLVGNQSKLEFY 119
            :.:|::..::|..:.::.||:.::   .||  ..:.:.|.:::..:.....||:| |:...:|..
Mouse   305 KDLLSFLQVQLENIRNSTPTMVMF---GCDMGSIRQIFEMSTQFGLSPPDLHWVL-GDSQNVEEL 365

  Fly   120 DLFGLFNISIDA----DVSYVKEQIQDNNDSVAYAV-------------------HDVYNNGKII 161
            ...|| .:.:.|    ..|..:..:||..:.||.||                   .||.......
Mouse   366 RTEGL-PLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTS 429

  Fly   162 G----------------GQLNVTGSHEMSC-----------DPFVCRRTRHLSSLQKRSKYGNR- 198
            |                |.:.|.||..:|.           ||........|.|.|     |.|
Mouse   430 GQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQ-----GGRI 489

  Fly   199 --------EQL----------TDVVLRVATVVTQRPLTLS---DDE------------------- 223
                    ||.          ..:.|||.|:: :.|...:   |||
Mouse   490 VMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLI-EHPFVFTREVDDEGLCPAGQLCLDPMTNDSSI 553

  Fly   224 ---LIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFS---------DSWSKSDVVGGSV 276
               |...|...|||......:..:...:.|.:.|...|.|.|.         .:| |:....|.|
Mouse   554 LDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW-KNGHWTGLV 617

  Fly   277 GAVVDQTADLTATPSLATEGRLKYLSAIIE--TGFFRSV--CIFRTPHNAGLRGDVFLQPFSPLV 337
            |.::..||::..|.......|    |.:|:  :.||.:.  .:.||...|...| .|:.   ||.
Mouse   618 GDLLSGTANMAVTSFSINTAR----SQVIDFTSPFFSTSLGILVRTRDTAAPIG-AFMW---PLH 674

  Fly   338 WYLFGGVLSLIGV-LLWITFY-------MECKRMQKRWRLDYLPSLLSTFLISFG-AACIQSSSL 393
            |.::.|:...:.: .:::|.|       |..|...:.....:..:|...:.:.|| .|.|:.
Mouse   675 WTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKP--- 736

  Fly   394 IPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQ------------- 440
             |:...||.:     .|.:|.:|     .||:.:.:.::...:..::..:..
Mouse   737 -PKCWTGRFLMNLWAIFCMFCLS-----TYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFG 795

  Fly   441 -LAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKR 474
             :.|||          .:.|:..| .||:|.:::|
Mouse   796 TVRESS----------AEDYVRQS-FPEMHEYMRR 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	28/166 (17%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	37/201 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	66/338 (20%)
		Lig_chan	676..942	CDD:278489	27/164 (16%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830