DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and Grin3a

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	100/557 - (17%)
Similarity:	186/557 - (33%)	Gaps:	181/557 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RGVLNWSHLELSYMGHTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVGNQSKLEFYDL 121
            :.:|::..:::..:.::.||:.:: ....|..:.:.|.:::..:.....||:| |:...:|....
  Rat   305 KDLLSFLQVQMDNIRNSTPTMVMF-GCDMDSIRQIFEMSTQFGLSPPELHWVL-GDSQNVEELRT 367

  Fly   122 FGLFNISIDA----DVSYVKEQIQDNNDSVAYAV-------------------HDVYNNGKIIG- 162
            .|| .:.:.|    ..|..:..:||..:.||.||                   .||.......|
  Rat   368 EGL-PLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQ 431

  Fly   163 ---------------GQLNVTGS---------------HEMSCDPFVCR---------------- 181
                           |.:.|.||               |:....|...|
  Rat   432 YLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIW 496

  Fly   182 ---RTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLS---DDE----------------- 223
               ..||.:..|..:|         :.|||.|:: :.|...:   |||
  Rat   497 PEQAQRHKTHFQHPNK---------LHLRVVTLI-EHPFVFTREVDDEGLCPAGQLCLDPMTNDS 551

  Fly   224 -----LIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFS---------DSWSKSDVVGG 274
                 |...|...|||......:..:...:.|.:.|...|.|.|.         .:| |:....|
  Rat   552 SMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW-KNGHWTG 615

  Fly   275 SVGAVVDQTADLTATPSLATEGRLKYLSAIIE--TGFFRSV--CIFRTPHNAGLRGDVFLQPFSP 335
            .||.::..||::..|.......|    |.:|:  :.||.:.  .:.||...|...| .|:.   |
  Rat   616 LVGDLLSGTANMAVTSFSINTAR----SQVIDFTSPFFSTSLGILVRTRDTAAPIG-AFMW---P 672

  Fly   336 LVWYLFGGVLSLIGV-LLWITFY-------MECKRMQKRWRLDYLPSLLSTFLISFG-AACIQSS 391
            |.|.::.|:...:.: .:::|.|       |..|...:.....:..:|...:.:.|| .|.|:.
  Rat   673 LHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKP- 736

  Fly   392 SLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQ----------- 440
               |:...||.:     .|.:|.:|     .||:.:.:.::...:..::..:..
  Rat   737 ---PKCWTGRFLMNLWAIFCMFCLS-----TYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFR 793

  Fly   441 ---LAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKR 474
               :.|||          .:.|:..| .||:|.:::|
  Rat   794 FGTVRESS----------AEDYVRQS-FPEMHEYMRR 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	28/166 (17%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	30/194 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	27/166 (16%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	67/347 (19%)
		Lig_chan	676..942	CDD:278489	27/164 (16%)
		PPP2CB binding site	951..987
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830