DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and glr-3

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	145/702 - (20%)
Similarity:	264/702 - (37%)	Gaps:	150/702 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IVLFHCWQSDESLKFAQQFMK-PIHPILVYHQFVQMRGVLNWSHLELSYMGHTQPTLAIYVDIKC 85
            :|:|.  :.||.|:....... ...|.....|.|:::...::.: ||.::.:......|.::|..
Worm   152 VVVFE--EPDELLEITDMITAGHFDPDSFSSQLVRLKHGDDYGN-ELKHIKNKLDRYRIVINIPL 213

  Fly    86 DQTQDLLEEASREQIYNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYA 150
            .:....||:|:...:....||::::.       .||     :::|.|..   ..|:|.| ..::.
Worm   214 QKALHFLEQAANMSMCGVLYHYVVMD-------MDL-----VTVDIDSI---RGIEDCN-ITSFG 262

  Fly   151 VHDV---------------------------------------------------------YNNG 158
            ||||                                                         :.:|
Worm   263 VHDVNSEYIEDIRQEIVHKSSIRLPKKGVPYTTSIWIDTLRLLIRSMKSIQIWDEPRCGSSWKSG 327

  Fly   159 KI------------IGGQLNVTGSHEMS-CDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVAT 210
            ..            |.|.|:...|.|.| ....|.|||   .|.||.:::.:|.:.......|..
Worm   328 SDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYRRT---LSFQKFAEWSSRTRRIASSEAVVI 389

  Fly   211 VVTQRPLTLSDDEL-IRFLSQENDTHIDSLARF-GFHLTLILRDLLHCK----MKFIFSDSWSKS 269
            ..:...|||....| |....:.....|.|...: |:.:     |||| |    :||.::....:.
Worm   390 ANSSEKLTLEGKHLKISVYLEAPFVMITSNGSYEGYCI-----DLLH-KIANILKFTYTIQKVRD 448

  Fly   270 DVVG---------GSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLR 325
            :..|         |.||.:....|||.......:.||.:.:...:.........:|:.|......
Worm   449 NAYGSKESNGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMHLGISILFKKPRIRDSD 513

  Fly   326 GDVFLQPFSPLVWYLFGGVLSLIGVLLW----ITFYMECKRMQKRWRLDYLP-----SLLSTFLI 381
            ...|:.|.|..||.:......::.|.:|    |:.|.:.:|.:...:  |.|     ||.::|..
Worm   514 WFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQ--YKPVDNQFSLRNSFWF 576

  Fly   382 SFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQL 441
            :..:...|.|.|.||:|..||:     :|||.|||     .||:.:.:.|.:..:::.|:....|
Worm   577 TVCSLMQQGSELCPRAASTRLLTGIWWFFALILIS-----SYTANLAAVLTTRRMETPIENADDL 636

  Fly   442 -AESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWL-PAEQGVLRVRDNPGYVY 504
             |::.:..|......|.|:.|.|::..    .:|..:..:.:|.|:: .:::|:.||:.: .|.|
Worm   637 AAQTKIKYGTLGRGSTMSFFNESKIET----YERMWQLMSSSPGLFVQSSKEGIARVKSS-DYAY 696

  Fly   505 VFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLRILE-TGVYRK 567
            :.|:|.....|||      .|:|.::....:|..| ..|.:.|.|:||.....||:.| |.:...
Worm   697 LMESSMLEYAVER------DCELMQIGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTEL 755

  Fly   568 QRSYWVHMKLHCVAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWKR 619
            :..:|....:.|...........|.:..:.::|:...:|..|:::.||...|
Worm   756 KEKWWKDKSVVCEQPKRKDQDDGESIGGIFIILVVGLVLTAVLVIFELITTR 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	67/283 (24%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	43/254 (17%)
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	89/383 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910