DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75a and gria2a

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	681	Identity:	132/681 - (19%)
Similarity:	241/681 - (35%)	Gaps:	193/681 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 IYVDIKCDQTQDLLEEASREQIYNQHYHWLLV------GNQSKLEFYDLFGLFNIS----IDADV 133
            :.:|.:.|:.:|::|:......:.:.||:::.      |:.||::    :|..|:|    :|.|.
Zfish   202 VILDCEQDKVKDIMEQVITIGRHVKGYHYIIANFGFVDGDLSKIQ----YGGANVSGFQIVDFDD 262

  Fly   134 SYV----------KEQIQDNNDS-VAYAVHDVY------------------------NNGKIIGG 163
            ..|          :|:.....|| :.|.....|                        |||..:..
Zfish   263 PLVAKFDQRWEALEEKEYPGADSRIRYTSALTYDAVQVMTEAFRFLHKQRIDISRRGNNGDCLAN 327

  Fly   164 ----------------QLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVAT-- 210
                            |:.|.|                |:...:..:||.|...|..|:.:..
Zfish   328 PAVPWAQGVEIERALKQVRVDG----------------LTGNIQFDQYGRRVNYTVNVMELKNSG 376

  Fly   211 -------------VVTQRPLTLSDDELIRFLSQENDTHI--------------------DSLARF 242
                         .||:..|..:|.     :..||.|.|                    |:....
Zfish   377 PVKIGYWNEMDKMAVTKSDLFPNDT-----MGMENKTVIVTTILEAPYVMLKKNAELFTDNERYE 436

  Fly   243 GFHLTLILRDLLHCKMKF---IFSDSW-----SKSDVVGGSVGAVVDQTADLTATP---SLATEG 296
            |:.:.|......||..|:   |.:|..     :::.:..|.||.:|...||:...|   :|..|.
Zfish   437 GYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITLVREE 501

  Fly   297 RLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECK 361
            .:.:....:..|.  |:.| :.|..:......||.|.:..:|...  |.:.|||.  :..::..:
Zfish   502 VIDFSKPFMSLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVSR 559

  Fly   362 RMQKRWRLDYL------PS-------LLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALF 408
            .....|..:..      ||       :.::...|.||...|...:.|||..||::     :|.|.
Zfish   560 FSPYEWHTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 624

  Fly   409 LISFIMYNYYTSVVVSSLLSSPVKS--KIKTMRQLAESSLTVGLEPLPFTKSYL-------NYSR 464
            :||....|....:.|..:: ||::|  .:....::|..:|..|.....|.:|.:       .|.:
Zfish   625 IISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIALFDKMWQYMK 688

  Fly   465 LPEIHLFIKRKIESQTQNPELWLPAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLN 528
            ..|..:|:|..:|              ||||||.:.| |.|:.|::     :..|...::.||..
Zfish   689 SAEPSVFVKNTVE--------------GVLRVRKSKGKYAYLLEST-----MNEYIEQRKPCDTM 734

  Fly   529 EVLFRPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHC-----VAQNFVIT 587
            :|....:...| ....:.|..:....|..|::.|.|:..|.::.|.:.|..|     .::.....
Zfish   735 KVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGESKEKTSA 799

  Fly   588 VGMEYVAPLLLMLICADILVVVILLVELAWK 618
            :.:..||.:..:|:....|.:::.|||..:|
Zfish   800 LSLSNVAGVFYILVGGLGLAMLVALVEFCYK 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	63/299 (21%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	32/208 (15%)
		ANF_receptor	51..373	CDD:279440	32/190 (17%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	85/403 (21%)
		Lig_chan	538..816	CDD:278489	63/301 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840