DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and Grin2d

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	530	Identity:	112/530 - (21%)
Similarity:	193/530 - (36%)	Gaps:	154/530 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SKYGNREQLTDVV--LRVATVVTQRPLTLSDD----------ELIRFLSQENDTH---------- 235
            |:||...|..|..  |.||| :.:||..:.:.          :.:...||.|.||
Mouse   419 SRYGRFLQPVDDTQHLTVAT-LEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSLVAPRSPPP 482

  Fly   236 --------------IDSLAR------FGFHLTLILRDLLHCKMKFIFSDSWSKSD-VVGGSVGAV 279
                          ||.|.|      |.:.|.|:... .|.|          |.| |..|.:|.|
Mouse   483 DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNG-KHGK----------KIDGVWNGMIGEV 536

  Fly   280 VDQTADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFL----------- 330
            ..|.||:........|.|   :.:....:|||.  ||.:.|:  |..:....||
Mouse   537 FYQRADMAIGSLTINEERSEIVDFSVPFVETGI--SVMVARS--NGTVSPSAFLAFAWLMPPMSP 597

  Fly   331 QPFSPLVW-YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLL-------STFLISFGA-- 385
            :|:||.|| .:|...|:::.|.::|..|:.        .:.|..||.       |||.|....
Mouse   598 EPYSPAVWVMMFVMCLTVVAVTVFIFEYLS--------PVGYNRSLATGKRPGGSTFTIGKSIWL 654

  Fly   386 --ACIQSSSL---IPRSAGGRL--IYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAE 443
              |.:.::|:   .||....::  :.:|.|.:.|:.  .||:.:.:.::.   :..:.|:..|::
Mouse   655 LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLA--SYTANLAAFMIQ---EEYVDTVSGLSD 714

  Fly   444 SS----------LTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWLPAEQGVLRVRD 498
            ..          |..|..|...|:..:. |..|::|.::.|..:.:         .|:.:.:::.
Mouse   715 RKFQRPQEQYPPLKFGTVPNGSTEKNIR-SNYPDMHSYMVRYNQPR---------VEEALTQLKA 769

  Fly   499 NPGYVYVFETSSGYAYVERYFTAQ-EICDLNEVLFRPEQLFYT-----HLHRNSTYKELFRLRFL 557
            .....::::     |.|..|...: |.|.|  |.....::|.|     .||:.|.:|....|..|
Mouse   770 GKLDAFIYD-----AAVLNYMARKDEGCKL--VTIGSGKVFATTGYGIALHKGSRWKRPIDLALL 827

  Fly   558 RILETGVYRKQRSYWVHMKLHCVAQNFVITV-----GMEYVAPLLLMLICADILVVVILLVELAW 617
            :.|...........|    |..:..|..|.|     .::.:|.:..||:.|    :.:.|:..||
Mouse   828 QFLGDDEIEMLERLW----LSGICHNDKIEVMSSKLDIDNMAGVFYMLLVA----MGLSLLVFAW 884

  Fly   618 KRFFTRHLTF 627
            :     ||.:
Mouse   885 E-----HLVY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	58/303 (19%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	95/466 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846347
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830