Protein Alignment Ir75a and Grin2c

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 640
• Identity: 122/640 - (19%)
• Similarity: 228/640 - (35%)
• Gaps: 195/640 - (30%)

  Fly    57 RGVLN--WSHLELSYM--GH-TQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVGNQSKL 116
            |.:||  |...:.|:.  |: .|||:.:..                   .|:|..|.:||..
Mouse   395 RHLLNVTWEGRDFSFSPGGYLVQPTMVVIA-------------------LNRHRLWEMVGRW--- 437

  Fly   117 EFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFV-- 179
                         |..|.|:|..:.....:....|.|        ...|.|....|.   |||
Mouse   438 -------------DHGVLYMKYPVWPRYSTSLQPVVD--------SRHLTVATLEER---PFVIV 478

  Fly   180 ----------------CRR-TRHLSS---LQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDEL 224
                            ||| :.|..|   :...:|...:....|::.::|.||
Mouse   479 ESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVV------------ 531

  Fly   225 IRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFSDSWSKSDVVGGSVGAVVDQTADLTAT 289
                            :|.:.|.|:.......:::.:    |:      |.:|.|..:.||:...
Mouse   532 ----------------KFSYDLYLVTNGKHGKRVRGV----WN------GMIGEVYYKRADMAIG 570

  Fly   290 PSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVW-YLFGGVLSLIGV 350
            .....|.|   :.:....:|||.  ||.:.|:  |..:....||:|:||.|| .:|...|:::.:
Mouse   571 SLTINEERSEIIDFSVPFVETGI--SVMVARS--NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAI 631

  Fly   351 LLWITFYMECKRMQKRWRLDYLPSLLS-------TFLISFGA----ACIQSSSL---IPRSAGGR 401
            .:::..|..        .:.|..:|..       :|.|....    |.:.::|:   .||....:
Mouse   632 TVFMFEYFS--------PVSYNQNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSK 688

  Fly   402 L--IYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESS----------LTVGLEPLP 454
            :  :.:|.|.:.|:.  .||:.:.:.::.   :..|.|:..|::..          ...|..|..
Mouse   689 IMVLVWAFFAVIFLA--SYTANLAAFMIQ---EQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNG 748

  Fly   455 FTKSYL--NYSRLPEIHL--FIKRKIESQTQNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYV 515
            .|:..:  || |....|:  |.:|.:|....:.::   ..:.|.|..|    .::::     |.|
Mouse   749 STERNIRSNY-RDMHTHMVKFNQRSVEDALTSLKM---GARHVSRKLD----AFIYD-----AAV 800

  Fly   516 ERYFTAQ-EICDLNEVLFRPEQLFYT-----HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVH 574
            ..|...: |.|.|  |.....::|.|     .:.::|.:|....|..|:.|..|..:|..:.|:.
Mouse   801 LNYMAGKDEGCKL--VTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS 863

  Fly   575 MKLHCVAQNFVIT--VGMEYVAPLLLMLICADILVVVILLVELAWKRFFTRHLTF 627
            ...| ..:|.|::  :.::.:|.:..||:.|    :.:.|:..||:     ||.:
Mouse   864 GICH-NEKNEVMSSKLDIDNMAGVFYMLLVA----MGLALLVFAWE-----HLVY 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/126 (21%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	17/85 (20%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	91/479 (19%)
		NMDAR2_C	905..>980	CDD:463148	2/4 (50%)