Protein Alignment Ir75a and Grin2b

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001350679.1
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 709
• Identity: 117/709 - (16%)
• Similarity: 230/709 - (32%)
• Gaps: 245/709 - (34%)

  Fly    75 PTLAIYVDIKC--DQTQDLLEEASREQIYNQHYHW----LLVGNQSKLEFYDLFGLFNISID--- 130
            |.:.:|    |  ::...:.|.|:...:....|.|    |:.|:...:......||.::|.|
Mouse   226 PIILLY----CTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWD 286

  Fly   131 ----------------------ADVSYVKEQIQDNNDSVAYAVHD--VYNNGKIIGGQLNVT--G 169
                                  ::.|::.|.     .|..|..|:  :|.:..:....:|||  |
Mouse   287 YGLPARVRDGIAIITTAASDMLSEHSFIPEP-----KSSCYNTHEKRIYQSNMLNRYLINVTFEG 346

  Fly   170 SH-EMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQEND 233
            .: ..|.|.:.......:..|.|..|:....:..|..|::...|..|....:::       ||:|
Mouse   347 RNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEE-------QEDD 404

  Fly   234 THIDSLARFGFHLTLI--------------------LRDLLHCKMKFIFSDSWSKSD-------- 270
                       ||:::                    :|:.:.|:.:.|   |.:|:|
Mouse   405 -----------HLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRII---SENKTDEEPGYIKK 455

  Fly   271 -------------------------------------VVGGSVGAVVDQTADLTATPSLATEGR- 297
                                                 ...|.:|.||.:.|.:........|.|
Mouse   456 CCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   298 --LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITF---- 356
              :.:....||||.  ||.:.|:  |..:....||:|||..||.:...:|.::..:....|
Mouse   521 EVVDFSVPFIETGI--SVMVSRS--NGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 581

  Fly   357 ---YMEC---------------KRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLI 403
               |..|               |.:...|.|.:..|:           .:|:    |:....:::
Mouse   582 PVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSV-----------PVQN----PKGTTSKIM 631

  Fly   404 --YFALFLISFIMYNYYTSVVVSSLLSSPVKSKI-----KTMRQLAESS--LTVGLEPLPFTKSY 459
              .:|.|.:.|:.  .||:.:.:.::......::     |..::..:.|  ...|..|...|:..
Mouse   632 VSVWAFFAVIFLA--SYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERN 694

  Fly   460 L--NYSRLPEIHLFIKRKIESQTQNPELWLPA-------------------EQGVLRVRDNPGYV 503
            :  ||:   |:|.::.:..:....:..|.|..                   ::|...|....|.|
Mouse   695 IRNNYA---EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKV 756

  Fly   504 YVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQ 568
            :   .|:||...                          :.::|.:|....|..|::...|...:.
Mouse   757 F---ASTGYGIA--------------------------IQKDSGWKRQVDLAILQLFGDGEMEEL 792

  Fly   569 RSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLICADILVVVILLVE-LAWKRFFTRH 624
            .:.|:....| ..:|.|::  :.::.:|.:..||..|..|.::..:.| |.:.:|  ||
Mouse   793 EALWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQF--RH 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	47/319 (15%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	30/170 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	71/467 (15%)
		NMDAR2_C	840..1482	CDD:402274	4/11 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930