Protein Alignment Ir75a and Grin2a

DIOPT Version :9

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 674
• Identity: 119/674 - (17%)
• Similarity: 213/674 - (31%)
• Gaps: 234/674 - (34%)

  Fly    39 QFMKPIHPILVYHQFVQMRGVLNWSHLELSYM--GH-TQPTLAIYVDIKCDQTQDLLEEASREQI 100
            |..||..|:...|||:..   :.|...:||:.  |: ..|.|.:.|
Mouse   323 QTEKPETPLHTLHQFMVN---VTWDGKDLSFTEEGYQVHPRLVVIV------------------- 365

  Fly   101 YNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQL 165
            .|:...|..||   |.|...|                        |:.:||...|.:..
Mouse   366 LNKDREWEKVG---KWENQTL------------------------SLRHAVWPRYKSFS------ 397

  Fly   166 NVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIR---- 226
                    .|:|    ...|||.               |.|..|..|....:....:..:|
Mouse   398 --------DCEP----DDNHLSI---------------VTLEEAPFVIVEDIDPLTETCVRNTVP 435

  Fly   227 ---FLSQENDTH-------------IDSL------ARFGFHLTLILRDLLHCKMKFIFSDSWSKS 269
               |:...|.|:             ||.|      .:|.:.|.|:... .|.|         ..:
Mouse   436 CRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG-KHGK---------KVN 490

  Fly   270 DVVGGSVGAVVDQTADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQ 331
            :|..|.:|.||.|.|.:........|.|   :.:....:|||.  ||.:.|:  |..:....||:
Mouse   491 NVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGI--SVMVSRS--NGTVSPSAFLE 551

  Fly   332 PFSPLVWYLFGGVLSLIGVLLWITF-YME---CKRMQKRWRLDYLPSL-------LSTFLISFGA 385
            |||..||.:...:|.::..:....| |..   ..|...:.:..:.||.       |...|:...:
Mouse   552 PFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNS 616

  Fly   386 ACIQSSSLIPRSAGGRLI--YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTV 448
            ..:|:    |:....:::  .:|.|.:.|:.  .||:.:.:.::......::            .
Mouse   617 VPVQN----PKGTTSKIMVSVWAFFAVIFLA--SYTANLAAFMIQEEFVDQV------------T 663

  Fly   449 GLEPLPFTKSYLNYS-------------------RLPEIHLFI----KRKIES-----QTQNPEL 485
            ||....|.:.: :||                   ..|.:|.::    :|.:|.     :|...:.
Mouse   664 GLSDKKFQRPH-DYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQRGVEDALVSLKTGKLDA 727

  Fly   486 WL----------PAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFYT 540
            ::          ..::|...|....||::   .::||...
Mouse   728 FIYDAAVLNYKAGRDEGCKLVTIGSGYIF---ATTGYGIA------------------------- 764

  Fly   541 HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLICA 603
             |.:.|.:|....|..|:.:..|...:..:.|:....| ..:|.|::  :.::.:|.:..||..|
Mouse   765 -LQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAA 827

  Fly   604 DILVVVILLVELAWKRFFTRHLTF 627
                :.:.|:...|:..|...|.|
Mouse   828 ----MALSLITFIWEHLFYWKLRF 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	46/318 (14%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	24/117 (21%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	81/476 (17%)
		HisJ	<458..>541	CDD:223904	23/96 (24%)
		Lig_chan	556..828	CDD:278489	47/324 (15%)
		NMDAR2_C	839..1464	CDD:287527	3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930