DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75a and Grik3

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	486	Identity:	99/486 - (20%)
Similarity:	189/486 - (38%)	Gaps:	124/486 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 GNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHC---- 256
            |....:||.:...:.:||    |:.::..:.|  :::|..:....||..:...:|::|.|.
Mouse   422 GRGPNVTDSLTNRSLIVT----TVLEEPFVMF--RKSDRTLYGNDRFEGYCIDLLKELAHILGFS 480

  Fly   257 -KMKFIFSDSWSKSDVVG---GSVGAVVDQTADLTATPSLATEGRLKYLSAIIETGFFRSV---C 314
             :::.:....:...|..|   |.|..::|..|||...|...|..|.|   ||..:..|.::   .
Mouse   481 YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREK---AIDFSKPFMTLGVSI 542

  Fly   315 IFRTPHNAGLRGDVFLQPFSPLVW------YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP 373
            ::|.|:........||.|.||.:|      ||  ||..::.|:...:.|        .| .|..|
Mouse   543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYL--GVSCVLFVIARFSPY--------EW-YDAHP 596

  Fly   374 ------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSV 421
                        :||::|....|:...|.|.|:|::...|:|     :|.|.:||     .||:.
Mouse   597 CNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS-----SYTAN 656

  Fly   422 VVSSLLSSPVKSKIKTMRQLAE------SSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQT 480
            :.:.|....::|.|.:...||:      .::..|.....|.||.:  |...::..|:..|..:..
Mouse   657 LAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKI--STFEKMWAFMSSKPSALV 719

  Fly   481 QNPELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEV----------LFRPE 535
            :|      .|:|:.|.. ...|..:.|:::    :| |.| |..|:|.::          :..|
Mouse   720 KN------NEEGIQRTL-TADYALLMESTT----IE-YIT-QRNCNLTQIGGLIDSKGYGIGTP- 770

  Fly   536 QLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-------------VIT 587
                    ..|.|::...:..|::.|..            |||.:.:.:             ...
Mouse   771 --------MGSPYRDKITIAILQLQEED------------KLHIMKEKWWRGSGCPEEENKEASA 815

  Fly   588 VGMEYVAPLLLMLICADILVVVILLVELAWK 618
            :|::.:..:.::|....:|.|::.:.|..:|
Mouse   816 LGIQKIGGIFIVLAAGLVLSVLVAVGEFIYK 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	60/317 (19%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	90/428 (21%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740