Protein Alignment Ir75a and Grid2

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_032193.1
• Gene: Grid2 / 14804
• MGIID: 95813
• Length: 1007
• Species: Mus musculus
• Alignment Length: 698
• Identity: 128/698 - (18%)
• Similarity: 265/698 - (37%)
• Gaps: 199/698 - (28%)

  Fly    11 LDNLVQSRIGFIVLF------------HCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWS 63
            :..||:..||.:.:.            .|::.:.  :.:.....|..|      |.|
Mouse   270 VQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNH--RISSSLCDPKDP------FAQ-------- 318

  Fly    64 HLELSYMGHTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYH--------------WLLVGNQS 114
            ::|:|       .|.||      .|..||..|..:::.::.:|              |  .|.:|
Mouse   319 NMEIS-------NLYIY------DTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPW--QGGRS 368

  Fly   115 KLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSC-DPF 178
            .||.....|:..::.|.:...     ...|.:|.:.:... |.|:.:|     .|..::.| :|.
Mouse   369 MLETIKKGGVNGLTGDLEFGE-----NGGNPNVHFEILGT-NYGEELG-----RGVRKLGCWNPV 422

  Fly   179 VCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELI----RFLSQENDTHIDSL 239
                |....||..:....|   :..|||||.||: :.|..:..:.::    ::.....|. :|:|
Mouse   423 ----TGLNGSLTDKKLENN---MRGVVLRVVTVL-EEPFVMVSENVLGKPKKYQGFSIDV-LDAL 478

  Fly   240 ARF-GFHLTLILRDLLHCKMKFIFSD----------SWSKSDVVGGSVGAVVDQTAD-----LTA 288
            :.: ||:..:           ::..|          :|:      |.||.:|.:.||     ||.
Mouse   479 SNYLGFNYEI-----------YVAPDHKYGSPQEDGTWN------GLVGELVFKRADIGISALTI 526

  Fly   289 TPSLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVF--LQPFSPLVWYLFGGVLSLIGVL 351
            ||.  .|..:.:.:..::  :...|.:.|.....    |:|  |.||...:|....|.:.|:|:|
Mouse   527 TPD--RENVVDFTTRYMD--YSVGVLLRRAEKTV----DMFACLAPFDLSLWACIAGTVLLVGLL 583

  Fly   352 LWITFYMECKRMQKRWRLDYLPSLLSTFLIS-----FGAACIQSSSLIPRSAGGRLIYFALFLIS 411
            :::..::...|:|       :.|:.||.|.:     :|:...|...:...:...|::..|.:|.:
Mouse   584 VYLLNWLNPPRLQ-------MGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFA 641

  Fly   412 FIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESSLTVGLEPLPF----TKSYLNYSRLPEIHLFI 472
            .|:.:.||:.:.:.|..:.::|.|::::.|::.:      .:|:    ..:...:.|:..::.|.
Mouse   642 LIVISSYTANLAAFLTITRIESSIQSLQDLSKQT------DIPYGTVLDSAVYQHVRMKGLNPFE 700

  Fly   473 KRKIESQTQNPELW-------------LPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEI 524
            :..:.||     :|             |.::.|:.:|:.. .|.:|::.:           ..|.
Mouse   701 RDSMYSQ-----MWRMINRSNGSENNVLESQAGIQKVKYG-NYAFVWDAA-----------VLEY 748

  Fly   525 CDLNEVLFRPEQLFYT------------HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKL 577
            ..:|:    |:..|||            .|...|.|:::|..|.|.:.::|.....:..|.....
Mouse   749 VAIND----PDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNG 809

  Fly   578 HCVAQNFVI------TVGMEYVAPLLLMLICADILVVVILLVELAWKR 619
            .|...:.|.      .:.::.:|.:..:|....:|..:|.::|..|.|
Mouse   810 QCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSR 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	23/145 (16%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		18/103 (17%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	35/204 (17%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	81/426 (19%)
		Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007