Protein Alignment Ir75a and Gria2

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 641
• Identity: 125/641 - (19%)
• Similarity: 236/641 - (36%)
• Gaps: 133/641 - (20%)

  Fly    47 ILVYHQFVQMRGVLNWSHL-ELSYMGHTQPTLAIYVDIKCDQTQDLLE----------EASR--- 97
            |:.|...:..:.:..||.| |..|.|....|:.....:..|..|.:.|          |.||
Mouse   262 IVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGN 326

  Fly    98 --EQIYNQHYHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGKI 160
              :.:.|....|                  ...::.:.:..:.|::..:.::.:.     .|||.
Mouse   327 AGDCLANPAVPW------------------GQGVEIERALKQVQVEGLSGNIKFD-----QNGKR 368

  Fly   161 IGGQLNV-----TGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLS 220
            |...:|:     .|..::.....|.:....|:.|...:.....|..|.||    |.:.:.|..
Mouse   369 INYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVV----TTILESPYV-- 427

  Fly   221 DDELIRFLSQENDTHIDSLARF-GFHLTLILRDLLHCKMKFIFSDSWSKSDVVG----------- 273
                   :.::|...::...|: |:.:.|......||..|:       |..:||
Mouse   428 -------MMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY-------KLTIVGDGKYGARDADT 478

  Fly   274 ----GSVGAVVDQTADLTATP---SLATEGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQ 331
                |.||.:|...||:...|   :|..|..:.:....:..|.  |:.| :.|..:......||.
Mouse   479 KIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI--SIMI-KKPQKSKPGVFSFLD 540

  Fly   332 PFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP--------------SLLSTFLIS 382
            |.:..:|...  |.:.|||.  :..::..:.....|..:...              .:.::...|
Mouse   541 PLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFS 601

  Fly   383 FGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKS--KIKTMRQ 440
            .||...|...:.|||..||::     :|.|.:||....|....:.|..:: ||::|  .:....:
Mouse   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTE 665

  Fly   441 LAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWL-PAEQGVLRVRDNPG-YV 503
            :|..:|..|     .||.:...|:   |.:|.|.....::..|.::: ...:||.|||.:.| |.
Mouse   666 IAYGTLDSG-----STKEFFRRSK---IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA 722

  Fly   504 YVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRK 567
            |:.|::     :..|...::.||..:|....:...| ....:.|:.:....|..|::.|.||..|
Mouse   723 YLLEST-----MNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDK 782

  Fly   568 QRSYWVHMKLHCVAQNF-----VITVGMEYVAPLLLMLICADILVVVILLVELAWK 618
            .::.|.:.|..|.|::.     ...:.:..||.:..:|:....|.:::.|:|..:|
Mouse   783 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	28/119 (24%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	25/158 (16%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	88/421 (21%)