DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75a and GRIN3A

DIOPT Version :10

Sequence 1:NP_649012.2 Gene:Ir75a / 39982 FlyBaseID:FBgn0036757 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:601 Identity:109/601 - (18%)
Similarity:189/601 - (31%) Gaps:226/601 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 IVLFHCWQSDESLK----FAQQF--MKPIHPILVYHQFVQMRGVLNWSH---------LELSYMG 71
            :|:|.|  ..||::    ...||  |.|           ::|.||..|.         |.|..:.
Human   325 VVMFGC--DMESIRRIFEITTQFGVMPP-----------ELRWVLGDSQNVEELRTEGLPLGLIA 376

  Fly    72 HTQPTLAIYVDIKCDQTQDLLE--------------------------EASREQIYNQHYHWLLV 110
            |.:.|.:::.    ...||.:|                          |.....:.:..|....:
Human   377 HGKTTQSVFE----HYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFL 437

  Fly   111 GNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHD-----------VYNNGKIIGGQ 164
            .|.:   |..|.|...:.....||      .:||..:....||           .:..|||:   
Human   438 ANTT---FRGLSGSIRVKGSTIVS------SENNFFIWNLQHDPMGKPMWTRLGSWQGGKIV--- 490

  Fly   165 LNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLS---DDE--- 223
                    |....:..:..||.:..|..||         :.|||.|:: :.|...:   |||   
Human   491 --------MDYGIWPEQAQRHKTHFQHPSK---------LHLRVVTLI-EHPFVFTREVDDEGLC 537

  Fly   224 -------------------LIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFS------ 263
                               |...|...|||......:..:...:.|.:.:...|.|.|.      
Human   538 PAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGD 602

  Fly   264 ---DSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLKYLSAIIE--TGFFRSV--CIFRTPHN 321
               .:| |:....|.||.::..||.:..|.......|    |.:|:  :.||.:.  .:.||...
Human   603 GKYGAW-KNGHWTGLVGDLLRGTAHMAVTSFSINTAR----SQVIDFTSPFFSTSLGILVRTRDT 662

  Fly   322 AGLRGDVFLQPFSPLVWYLFGGVLSLIGV-LLWITFYMECKRMQKRWRLDYLPSLLSTF------ 379
            |...| .|:.   ||.|.::.|:...:.: .:::|.|        .|:        |.|      
Human   663 AAPIG-AFMW---PLHWTMWLGIFVALHITAVFLTLY--------EWK--------SPFGLTPKG 707

  Fly   380 -----LISFGAACIQSSSLI---------PRSAGGRLI-----YFALFLISFIMYNYYTSVVVSS 425
                 :.||.:|.....:|:         |:...||.:     .|.:|.:|     .||:.:.:.
Human   708 RNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLS-----TYTANLAAV 767

  Fly   426 LLSSPVKSKIKTMRQ--------------LAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKR-- 474
            ::...:..::..:..              :.|||          .:.|:..| .||:|.:::|  
Human   768 MVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESS----------AEDYVRQS-FPEMHEYMRRYN 821

  Fly   475 ------KIESQTQNPE 484
                  .:|....:||
Human   822 VPATPDGVEYLKNDPE 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75aNP_649012.2 Periplasmic_Binding_Protein_Type_2 455..572 CDD:473866 9/38 (24%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 40..496 CDD:380600 36/207 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 69/377 (18%)
Lig_chan 674..941 CDD:459656 31/196 (16%)
PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7 951..987
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.

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