DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	601	Identity:	109/601 - (18%)
Similarity:	189/601 - (31%)	Gaps:	226/601 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IVLFHCWQSDESLK----FAQQF--MKPIHPILVYHQFVQMRGVLNWSH---------LELSYMG 71
            :|:|.|  ..||::    ...||  |.|           ::|.||..|.         |.|..:.
Human   325 VVMFGC--DMESIRRIFEITTQFGVMPP-----------ELRWVLGDSQNVEELRTEGLPLGLIA 376

  Fly    72 HTQPTLAIYVDIKCDQTQDLLE--------------------------EASREQIYNQHYHWLLV 110
            |.:.|.:::.    ...||.:|                          |.....:.:..|....:
Human   377 HGKTTQSVFE----HYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFL 437

  Fly   111 GNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHD-----------VYNNGKIIGGQ 164
            .|.:   |..|.|...:.....||      .:||..:....||           .:..|||:
Human   438 ANTT---FRGLSGSIRVKGSTIVS------SENNFFIWNLQHDPMGKPMWTRLGSWQGGKIV--- 490

  Fly   165 LNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLS---DDE--- 223
                    |....:..:..||.:..|..||         :.|||.|:: :.|...:   |||
Human   491 --------MDYGIWPEQAQRHKTHFQHPSK---------LHLRVVTLI-EHPFVFTREVDDEGLC 537

  Fly   224 -------------------LIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFS------ 263
                               |...|...|||......:..:...:.|.:.:...|.|.|.
Human   538 PAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGD 602

  Fly   264 ---DSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLKYLSAIIE--TGFFRSV--CIFRTPHN 321
               .:| |:....|.||.::..||.:..|.......|    |.:|:  :.||.:.  .:.||...
Human   603 GKYGAW-KNGHWTGLVGDLLRGTAHMAVTSFSINTAR----SQVIDFTSPFFSTSLGILVRTRDT 662

  Fly   322 AGLRGDVFLQPFSPLVWYLFGGVLSLIGV-LLWITFYMECKRMQKRWRLDYLPSLLSTF------ 379
            |...| .|:.   ||.|.::.|:...:.: .:::|.|        .|:        |.|
Human   663 AAPIG-AFMW---PLHWTMWLGIFVALHITAVFLTLY--------EWK--------SPFGLTPKG 707

  Fly   380 -----LISFGAACIQSSSLI---------PRSAGGRLI-----YFALFLISFIMYNYYTSVVVSS 425
                 :.||.:|.....:|:         |:...||.:     .|.:|.:|     .||:.:.:.
Human   708 RNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLS-----TYTANLAAV 767

  Fly   426 LLSSPVKSKIKTMRQ--------------LAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKR-- 474
            ::...:..::..:..              :.|||          .:.|:..| .||:|.:::|
Human   768 MVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESS----------AEDYVRQS-FPEMHEYMRRYN 821

  Fly   475 ------KIESQTQNPE 484
                  .:|....:||
Human   822 VPATPDGVEYLKNDPE 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	31/196 (16%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	36/208 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	30/169 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	69/377 (18%)
		Lig_chan	676..942	CDD:278489	30/194 (15%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830