Protein Alignment Ir75a and grin3b

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_017952374.2
• Gene: grin3b / 100497172
• XenbaseID: XB-GENE-990106
• Length: 1005
• Species: Xenopus tropicalis
• Alignment Length: 802
• Identity: 147/802 - (18%)
• Similarity: 246/802 - (30%)
• Gaps: 336/802 - (41%)

  Fly    22 IVLFHCWQS------------------------DES--LKFAQQFMK----PIHPILVY------ 50
            |:..|.|.|                        |||  :.|.||..:    |..|:|:|
 Frog   176 IITCHPWDSASIQRYLTSNTTLVSRTILNIHPVDESALVPFLQQHFESMKNPQFPMLLYGCDARR 240

  Fly    51 ---------------HQFVQMRG-VLNWSHL---------------------------------E 66
                           |:|..|.| .||...:                                 .
 Frog   241 SSLVFRVARDCGLEAHEFHWMIGHPLNGEEMTTEGMPPGLLAYGEVSRPTMEKFIRDAVGLVTRA 305

  Fly    67 LSYMGHTQPTLAIYVD-IKCDQTQDLLEEASRE----------------QIY--------NQHYH 106
            :|...|.:|.||:... :.|:..|....|:|..                |||        ..||.
 Frog   306 ISAAVHVRPDLALIQSMVNCNDKQTKQNESSGSYLSRFLANTSFSGQTGQIYVSNNLIHTEHHYR 370

  Fly   107 -------------WLLVG--NQSKLEFYDLFGLFNISID----ADVSYVKEQIQDNNDSVAYAVH 152
                         |:.||  .|.|:|..:  ||:...|.    |...:.:.:::    .|....|
 Frog   371 IWSLVRDSLGDPTWVTVGGWRQGKMEVEE--GLWQSRIQQWEPAPGGFARTKLR----VVTLVEH 429

  Fly   153 ------DVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSSL-----QKRSKYGNREQLTDVVL 206
                  :|..:|....||        |..||    ||.:.:.|     :..|..|:      |.|
 Frog   430 PFVFTREVDADGSCPAGQ--------MCLDP----RTNNSAVLDVLFEELNSPNGS------VPL 476

  Fly   207 RVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIFSDSWSKSDV 271
            ...|......:     :|:..||::        .||.|.| .|:.|..:...|   .|.|:
 Frog   477 EYKTCCYGYCI-----DLLEKLSED--------LRFDFEL-YIVGDGKYGARK---GDRWT---- 520

  Fly   272 VGGSVGAVVDQTADLTATPSLATEGRLKYLSAIIE-TGFFRSV---CIFRTPHNAGLRGDVFLQP 332
              |.||.::...|.:..|.......|    |.:|: |..|.|.   .:.|....|...| .|:.
 Frog   521 --GLVGDLLSGAAHMAVTSFSINSAR----STVIDFTSPFYSTSLGILVRMRDTASPIG-AFMW- 577

  Fly   333 FSPLVWYLFGGVLSLIGV-LLWITFYMECKRMQKRWR---------------LDYLPSLLSTFLI 381
              ||.|.::.|:...:.: .|::|||        .|:               ..|..:|...:.|
 Frog   578 --PLHWSMWVGIFVALHITALFLTFY--------EWKSPFGMTPHGRNRTKIFSYSSALNLCYAI 632

  Fly   382 SFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLA---- 442
            .||...   ||..|:...||::.....:...::.:.||:.:.:.::..      ||...|:
 Frog   633 LFGRTV---SSKTPKCCTGRVLMNLWAIFCLLVLSSYTANLAAVMVGD------KTFEALSGIHD 688

  Fly   443 ----------------ESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKR-------------KIES 478
                            |||          .:.|:..| .||:|.::::             |.:.
 Frog   689 PKLHHPSQGFRFGTVWESS----------AEQYIKKS-FPEMHNYMRKFSVPATSDGVHLLKTDP 742

  Fly   479 QTQNP----------ELWLPAEQGVLRVRDNPGYVYVFE------------TSSGYAYVERYFTA 521
            .|.|.          |:.:.::..:|.:    |..:..|            ||:...::.||.::
 Frog   743 PTLNAFIMDKALLDYEVSIDSDCKLLTI----GKPFAIEGYGIGLPQNSPLTSNISEFISRYKSS 803

  Fly   522 QEICDLNEVLFR-----------PEQLFYTHLHRNSTYKELFRLRFL--------RILETGVY-- 565
            ..:..|::..::           .|.|.....|    :..||.|..:        .::|..||
 Frog   804 GFMDTLHDKWYKMVPCGKRVYAVTETLQMGIYH----FSGLFVLLCIGFCGSLLTSLMERVVYHL 864

  Fly   566 -------RKQRSYWVH--MKLH 578
                   |::..||:|  .|:|
 Frog   865 ILPRIRRRRRFKYWLHTSQKIH 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/179 (15%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	41/227 (18%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	88/480 (18%)
		Lig_chan	580..847	CDD:459656	48/302 (16%)