Protein Alignment Ir75a and grin2b

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 669
• Identity: 118/669 - (17%)
• Similarity: 221/669 - (33%)
• Gaps: 212/669 - (31%)

  Fly    27 CWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHLELSYMGHTQPTLAIYVDIKCDQTQDL 91
            |:...||..:....:|.      |...|...| .|.|..|..|..|  |.|.|.
 Frog   316 CYNIQESRVYEAHMLKR------YLINVTFEG-RNLSFSEDGYQMH--PKLVII----------- 360

  Fly    92 LEEASREQIYNQHYHWLLVGNQS----KLEFY--DLFGLFNISIDADVSYVKEQIQDNNDSVA-- 148
                    :.||...|..||...    |:::|  .:|.|:..|         |:.:|.:.|:.
 Frog   361 --------LLNQQRKWERVGKYKDRSLKMKYYVWPVFELYPNS---------EEHKDEHLSIVTL 408

  Fly   149 -----YAVHDVYNNGKIIGGQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQ-------- 200
                 ..|.||                     ||......|:....:|:.:..||.:
 Frog   409 EEAPFVIVEDV---------------------DPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKR 452

  Fly   201 -----LTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKF 260
                 ..|::.::|..|                            :|.:.|.|:... .|.|.
 Frog   453 CCKGFCIDILKKIAKTV----------------------------KFTYDLYLVTNG-KHGKK-- 486

  Fly   261 IFSDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNA 322
             .:.:|:      |.:|.||.:.|.:........|.|   :.:....||||.  ||.:.|:  |.
 Frog   487 -INGTWN------GMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGI--SVMVSRS--NG 540

  Fly   323 GLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITF-------YMEC---------------KRMQK 365
            .:....||:|||..||.:...:|.::..:....|       |..|               |.:..
 Frog   541 TVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWL 605

  Fly   366 RWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLI--YFALFLISFIMYNYYTSVVVSSLLS 428
            .|.|.:..|:           .:|:    |:....:::  .:|.|.:.|:.  .||:.:.:.::.
 Frog   606 LWGLVFNNSV-----------PVQN----PKGTTSKIMVSVWAFFAVIFLA--SYTANLAAFMIQ 653

  Fly   429 SPVKSKIKTMRQLA-------ESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELW 486
            .....::..:....       ..:...|..|...|:..:..:.| |:|.::.:..:...|:
 Frog   654 EEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYL-EMHSYMVKFNQRSVQD---- 713

  Fly   487 LPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQ-EICDLNEVLFRPEQLFYT-----HLHRN 545
                 .:|.::......::::     |.|..|...: |.|.|  |.....::|.|     .:.::
 Frog   714 -----ALLSLKTGKLDAFIYD-----AAVLNYMAGRDEGCKL--VTIGSGKVFATTGYGIAIQKD 766

  Fly   546 STYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNFVIT--VGMEYVAPLLLMLICADILVV 608
            |.:|....|..|::...|...:..:.|:....| ..:|.|::  :.::.:|.:..||..|..|.:
 Frog   767 SGWKRQVDLAILQLFGDGEMEELEALWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMALSL 830

  Fly   609 VILLVELAWKRFFTRHLTF 627
            :..::|         ||.|
 Frog   831 ITFIME---------HLFF 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	20/122 (16%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	21/94 (22%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	81/497 (16%)
		NMDAR2_C	837..1449	CDD:463148	3/4 (75%)