DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75a and gria4

DIOPT Version :9

Sequence 1:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_031751480.1	Gene:	gria4 / 100125052	XenbaseID:	XB-GENE-5838893	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	454	Identity:	92/454 - (20%)
Similarity:	184/454 - (40%)	Gaps:	75/454 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 VATVVTQRPLTL--SDDELIRFLSQENDTHIDSLARF-GFHLTLILRDLLHCKMKF---IFSDSW 266
            :.|.:.:.|..:  .:.||:    :.||       :| |:.:.|......|..:|:   |..|..
Frog   418 IVTTILEAPYVMYKKNHELL----EGND-------KFEGYCVDLAYEIAKHIGIKYKIAIVPDGK 471

  Fly   267 -----SKSDVVGGSVGAVVDQTADLTATP---SLATEGRLKYLSAIIETGFFRSVCIFRTPHNAG 323
                 |::.:..|.||.:|...|::...|   :|..|..:.:....:..|.  |:.| :.|..:.
Frog   472 YGARDSETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGI--SIMI-KKPQKSK 533

  Fly   324 LRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRL-----------DYLPS--- 374
            .....||.|.:..:|...  |.:.|||.  :..::..:.....|..           |..|:
Frog   534 PGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFG 594

  Fly   375 LLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSSPVKS- 433
            :.::...|.||...|...:.|||..||::     :|.|.:||....|....:.|..:: ||::|
Frog   595 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESA 658

  Fly   434 -KIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQTQNPELWL-PAEQGVLRV 496
             .:....::|..:|..|     .||.:...|:   |.::.|.....::..|.::. ...:||.||
Frog   659 EDLAKQTEIAYGTLDAG-----STKEFFKRSK---IAVYEKMWTYMKSAEPSVFTKTTAEGVARV 715

  Fly   497 RDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-THLHRNSTYKELFRLRFLRI 559
            |.:.| :.::.|::     :..|...::.||..:|....:...| ....::|..:....|..|::
Frog   716 RKSKGKFAFLLEST-----MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRNAVNLAVLKL 775

  Fly   560 LETGVYRKQRSYWVHMKLHC-----VAQNFVITVGMEYVAPLLLMLICADILVVVILLVELAWK 618
            .|.|:..|.::.|.:.|..|     .:::....:.:..||.:..:|:....|.:::.|:|..:|
Frog   776 NEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	59/294 (20%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611
gria4	XP_031751480.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	84/408 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100